Laboratory of Animal Reproduction and Physiology, Department of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon 305-764, Korea.
Laboratory of Animal Reproduction and Physiology, Department of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon 305-764; Department of Biology Education, College of Education, Chonnam National University, Gwangju 500-757, Korea.
BMB Rep. 2014 Mar;47(3):135-40. doi: 10.5483/bmbrep.2014.47.3.289.
The mesenchymal stem cells (MSCs), which are derived from the mesoderm, are considered as a readily available source for tissue engineering. They have multipotent differentiation capacity and can be differentiated into various cell types. Many studies have demonstrated that the MSCs identified from amniotic membrane (AM-MSCs) and amniotic fluid (AF-MSCs) are shows advantages for many reasons, including the possibility of noninvasive isolation, multipotency, self-renewal, low immunogenicity, anti-inflammatory and nontumorigenicity properties, and minimal ethical problem. The AF-MSCs and AM-MSCs may be appropriate sources of mesenchymal stem cells for regenerative medicine, as an alternative to embryonic stem cells (ESCs). Recently, regenerative treatments such as tissue engineering and cell transplantation have shown potential in clinical applications for degenerative diseases. Therefore, amnion and MSCs derived from amnion can be applied to cell therapy in neuro-degeneration diseases. In this review, we will describe the potential of AM-MSCs and AF-MSCs, with particular focus on cures for neuronal degenerative diseases.
间充质干细胞（MSCs）来源于中胚层，被认为是组织工程的一种现成来源。它们具有多能分化能力，可以分化为多种细胞类型。许多研究表明，从羊膜（AM-MSCs）和羊水（AF-MSCs）中鉴定出的 MSCs 具有多种优势，包括非侵入性分离、多能性、自我更新、低免疫原性、抗炎和非致瘤性以及最小的伦理问题。AF-MSCs 和 AM-MSCs 可能是再生医学中间充质干细胞的合适来源，可作为胚胎干细胞（ESCs）的替代品。最近，组织工程和细胞移植等再生疗法已显示出在退行性疾病的临床应用中的潜力。因此，羊膜和羊膜衍生的 MSCs 可应用于神经退行性疾病的细胞治疗。在这篇综述中，我们将描述 AM-MSCs 和 AF-MSCs 的潜力，特别关注神经元退行性疾病的治疗方法。
