Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai 200040, China; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, PR China.
Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
J Mol Biol. 2018 Sep 28;430(19):3504-3520. doi: 10.1016/j.jmb.2017.09.013. Epub 2017 Sep 27.
Asymmetric local concentration of protein complexes on distinct membrane regions is a fundamental property in numerous biological processes and is a hallmark of cell polarity. Evolutionarily conserved core polarity proteins form specific and dynamic networks to regulate the establishment and maintenance of cell polarity, as well as distinct polarity-driven cellular events. This review focuses on the molecular and structural basis governing regulated formation of several sets of core cell polarity regulatory complexes, as well as their functions in epithelial cell polarization and asymmetric cell division.
蛋白质复合物在不同膜区域的不对称局域化是众多生物过程中的一个基本特性，也是细胞极性的一个标志。进化上保守的核心极性蛋白形成特定的和动态的网络来调节细胞极性的建立和维持，以及不同的极性驱动的细胞事件。这篇综述集中讨论了调控几套核心细胞极性调控复合物形成的分子和结构基础，以及它们在上皮细胞极化和不对称细胞分裂中的功能。
