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铜绿假单胞菌引起的血流感染：如何直接从血培养物中检测碳青霉烯酶产生菌。

Bloodstream infections caused by Pseudomonas spp.: how to detect carbapenemase producers directly from blood cultures.

作者信息

Dortet Laurent, Boulanger Anne, Poirel Laurent, Nordmann Patrice

机构信息

INSERM U914 "Emerging Resistance to Antibiotics," South-Paris Medical School, K.-Bicêtre, France.

出版信息

J Clin Microbiol. 2014 Apr;52(4):1269-73. doi: 10.1128/JCM.03346-13. Epub 2014 Feb 5.

DOI:10.1128/JCM.03346-13
PMID:24501031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3993505/
Abstract

The Carba NP test has been evaluated to detect carbapenemase-producing Pseudomonas spp. directly from blood cultures. This rapid and cost-effective test permits an early identification of carbapenemase-producing Pseudomonas spp. directly from blood cultures with excellent sensitivity and specificity. Results may be useful in particular for guiding the first-line therapy and epidemiological purposes.

摘要

已对碳青霉烯酶检测（Carba NP）试验进行评估，以直接从血培养物中检测产碳青霉烯酶的假单胞菌属。这项快速且经济高效的试验能够直接从血培养物中早期鉴定出产碳青霉烯酶的假单胞菌属，具有出色的敏感性和特异性。其结果对于指导一线治疗及流行病学目的可能尤其有用。

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本文引用的文献

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Rapid detection of carbapenemase-producing Enterobacteriaceae from blood cultures.血培养中碳青霉烯酶产生肠杆菌科的快速检测。
Clin Microbiol Infect. 2014 Apr;20(4):340-4. doi: 10.1111/1469-0691.12318. Epub 2013 Jul 24.
2
FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy.FIM-1，一种从意大利分离的铜绿假单胞菌临床株获得的新型金属β-内酰胺酶。
Antimicrob Agents Chemother. 2013 Jan;57(1):410-6. doi: 10.1128/AAC.01953-12. Epub 2012 Oct 31.
3
Rapid detection of carbapenemase-producing Pseudomonas spp.快速检测产碳青霉烯酶铜绿假单胞菌
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Rapid detection of extended-spectrum-β-lactamase-producing Enterobacteriaceae.产超广谱β-内酰胺酶肠杆菌科的快速检测。
J Clin Microbiol. 2012 Sep;50(9):3016-22. doi: 10.1128/JCM.00859-12. Epub 2012 Jul 3.
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Interventional strategies and current clinical experience with carbapenemase-producing Gram-negative bacteria.产碳青霉烯酶革兰氏阴性菌的介入策略和当前临床经验。
Clin Microbiol Infect. 2012 May;18(5):439-48. doi: 10.1111/j.1469-0691.2012.03823.x.
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