Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden.
Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden.
Psychiatry Res. 2014 Mar 30;215(3):646-50. doi: 10.1016/j.psychres.2014.01.009. Epub 2014 Jan 16.
An association between low levels of serum cholesterol and violent or suicidal behaviour has frequently been reported. However the role of serum cholesterol in the cycle of violence (Widom, 1989) has not been studied. The aim of this study was to investigate association between exposure to violence during childhood and used adult violence in suicide attempters with low and high serum cholesterol levels. 81 suicide attempters were assessed with the Karolinska Interpersonal Violence Scale (KIVS) measuring exposure to violence and expressed violent behaviour in childhood (between 6 and 14 years of age) and during adult life (15 years or older). We used median split to dichotomise groups below and above median serum cholesterol. In patients with serum cholesterol below median, the correlation between exposure to violence as a child and used adult violence was significant (rho=0.52, p=0.002), while in patients with serum cholesterol above median, the correlation between exposure to violence as a child and expressed violent behaviour as an adult was not significant (rho=0.25, p=0.2). Comorbid substance abuse predicted violent behaviour as an adult only in patients with serum cholesterol above median. Serum cholesterol may modify the effect of the "Cycle of Violence".
血清胆固醇水平低与暴力或自杀行为之间的关联经常被报道。然而，血清胆固醇在暴力循环中的作用（Widom，1989）尚未得到研究。本研究旨在调查儿童期遭受暴力与低和高血清胆固醇水平自杀未遂者成年暴力之间的关联。81 名自杀未遂者接受了卡罗林斯卡人际暴力量表（KIVS）的评估，该量表用于测量儿童时期（6 至 14 岁）和成年期（15 岁及以上）的暴力暴露和表达的暴力行为。我们使用中位数分割将血清胆固醇低于和高于中位数的组进行二分。在血清胆固醇低于中位数的患者中，儿童时期的暴力暴露与成年期使用暴力之间的相关性显著（rho=0.52，p=0.002），而在血清胆固醇高于中位数的患者中，儿童时期的暴力暴露与成年期表达的暴力行为之间的相关性不显著（rho=0.25，p=0.2）。合并物质滥用仅在血清胆固醇高于中位数的患者中预测成年期的暴力行为。血清胆固醇可能会改变“暴力循环”的作用。
