负载光敏剂的纳米石墨烯用于多模态成像引导的肿瘤光动力治疗。
Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy.
作者信息
Rong Pengfei, Yang Kai, Srivastan Avinash, Kiesewetter Dale O, Yue Xuyi, Wang Fu, Nie Liming, Bhirde Ashwinkumar, Wang Zhe, Liu Zhuang, Niu Gang, Wang Wei, Chen Xiaoyuan
机构信息
1. Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China ; 2. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States ; 3. State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan, 410083, China.
2. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States ; 4. Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China.
出版信息
Theranostics. 2014 Jan 15;4(3):229-39. doi: 10.7150/thno.8070. eCollection 2014.
Graphene, a 2-dimensional carbon nanomaterial, has attracted wide attention in biomedical applications, owing to its intrinsic physical and chemical properties. In this work, a photosensitizer molecule, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha (HPPH or Photochlor®), is loaded onto polyethylene glycol (PEG)-functionalized graphene oxide (GO) via supramolecular π-π stacking. The obtained GO-PEG-HPPH complex shows high HPPH loading efficiency. The in vivo distribution and delivery were tracked by fluorescence imaging as well as positron emission tomography (PET) after radiolabeling of HPPH with (64)Cu. Compared with free HPPH, GO-PEG-HPPH offers dramatically improved photodynamic cancer cell killing efficacy due to the increased tumor delivery of HPPH. Our study identifies a role for graphene as a carrier of PDT agents to improve PDT efficacy and increase long-term survival following treatment.
石墨烯是一种二维碳纳米材料，由于其固有的物理和化学性质，在生物医学应用中引起了广泛关注。在这项工作中，一种光敏剂分子，即2-(1-己氧基乙基)-2-去乙烯基焦脱镁叶绿酸-α（HPPH或光动力治癌药），通过超分子π-π堆积负载到聚乙二醇（PEG）功能化的氧化石墨烯（GO）上。所得到的GO-PEG-HPPH复合物显示出高HPPH负载效率。在用(64)Cu对HPPH进行放射性标记后，通过荧光成像以及正电子发射断层扫描（PET）追踪其在体内的分布和递送情况。与游离的HPPH相比，GO-PEG-HPPH由于HPPH在肿瘤部位的递送增加，显著提高了光动力杀伤癌细胞的疗效。我们的研究确定了石墨烯作为光动力疗法（PDT）药物载体的作用，可提高PDT疗效并增加治疗后的长期生存率。
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