Department of Human Biology, Nutrition and Toxicology Research Institute (NUTRIM) - School for Nutrition Toxicology and Metabolism, Maastricht University Medical Center (MUMC+), Universiteit Single (UNS), 50, PO Box 616, 6200 MD Maastricht, The Netherlands.
Br J Nutr. 2014 May 28;111(10):1853-61. doi: 10.1017/S0007114514000014. Epub 2014 Feb 10.
For the same BMI, South Asians have a higher body fat percentage and an adverse metabolic profile compared with whites. The objective of the present study was to determine the metabolic profiles of South Asian and white men matched for body fat percentage in response to short-term overfeeding with a high-fat diet. A total of ten healthy non-diabetic South Asian men matched for body fat percentage with ten white men were included in the study. A weight-maintenance diet (containing 30 % fat, 55 % carbohydrate and 15 % protein) was provided for 3 d followed by 4 d of overfeeding (150 % of energy requirement) with a high-fat diet (60 % fat, 25 % carbohydrate and 15 % protein). Before and after the overfeeding period, plasma glucose, insulin, TAG, NEFA, total cholesterol and HDL-cholesterol concentrations were determined. Glucose clearance was calculated using a 2 h oral glucose tolerance test. The results revealed that in South Asian and white men, respectively, overfeeding with a high-fat diet decreased plasma TAG concentrations by 0·4 (sd 0·6) and 0·4 (sd 0·5) mmol/l (P diet= 0·008; P ethnicity= 0·24), increased HDL-cholesterol concentrations by 0·12 (sd 0·1) and 0·14 (sd 0·2) mmol/l (P diet= 0·001; P ethnicity= 0·06) and decreased glucose clearance by 48·8 (sd 53·5) and 37·2 (sd 34·2) ml/min per m2 body surface (P diet= 0·004; P ethnicity= 0·18). There was a significant interaction between diet and ethnicity with regard to the changes in total and LDL-cholesterol concentrations (P= 0·01 and 0·007, respectively), which trended towards a larger increase in South Asian subjects than in white subjects. Despite a similar body fat percentage, short-term overfeeding with a high-fat diet had more adverse effects on the lipid profile of South Asians than on that of whites.
对于相同的 BMI，南亚人比白人具有更高的体脂百分比和不良的代谢特征。本研究的目的是确定南亚人和白人男性在短期高脂饮食喂养下，根据体脂百分比相匹配的代谢特征。本研究共纳入 10 名健康的非糖尿病南亚男性和 10 名白人男性，他们的体脂百分比相匹配。研究对象先接受 3 天的维持体重饮食（含 30%脂肪、55%碳水化合物和 15%蛋白质），然后进行 4 天的高脂饮食（60%脂肪、25%碳水化合物和 15%蛋白质）喂养，摄入能量为 150%的能量需求。在喂养前和喂养后，测定血浆葡萄糖、胰岛素、三酰甘油(TAG)、非酯化脂肪酸(NEFA)、总胆固醇和高密度脂蛋白胆固醇(HDL-cholesterol)浓度。通过口服葡萄糖耐量试验，计算葡萄糖清除率。结果显示，在南亚人和白人男性中，高脂饮食喂养分别使血浆 TAG 浓度降低 0.4(标准差 0.6)和 0.4(标准差 0.5)mmol/L(P 饮食=0.008；P 种族=0.24)，HDL-cholesterol 浓度升高 0.12(标准差 0.1)和 0.14(标准差 0.2)mmol/L(P 饮食=0.001；P 种族=0.06)，葡萄糖清除率降低 48.8(标准差 53.5)和 37.2(标准差 34.2)ml/min·m2 体表面积(P 饮食=0.004；P 种族=0.18)。饮食和种族对总胆固醇和 LDL 胆固醇浓度的变化有显著的交互作用(P=0.01 和 0.007)，南亚人的变化趋势大于白人。尽管体脂百分比相似，但短期高脂饮食喂养对南亚人的血脂谱的不良影响大于白人。
