Parry Siôn A, Woods Rachel M, Hodson Leanne, Hulston Carl J
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
Nutrients. 2017 Jul 29;9(8):818. doi: 10.3390/nu9080818.
Consuming excessive amounts of energy as dietary fat for several days or weeks can impair glycemic control and reduce insulin sensitivity in healthy adults. However, individuals who demonstrate binge eating behavior overconsume for much shorter periods of time; the metabolic consequences of such behavior remain unknown. The aim of this study was to determine the effect of a single day of high-fat overfeeding on whole-body insulin sensitivity. Fifteen young, healthy adults underwent an oral glucose tolerance test before and after consuming a high-fat (68% of total energy), high-energy (78% greater than daily requirements) diet for one day. Fasting and postprandial plasma concentrations of glucose, insulin, non-esterified fatty acids, and triglyceride were measured and the Matsuda insulin sensitivity index was calculated. One day of high-fat overfeeding increased postprandial glucose area under the curve (AUC) by 17.1% ( < 0.0001) and insulin AUC by 16.4% ( = 0.007). Whole-body insulin sensitivity decreased by 28% ( = 0.001). In conclusion, a single day of high-fat, overfeeding impaired whole-body insulin sensitivity in young, healthy adults. This highlights the rapidity with which excessive consumption of calories through high-fat food can impair glucose metabolism, and suggests that acute binge eating may have immediate metabolic health consequences for the individual.
连续几天或几周摄入过量的膳食脂肪形式的能量，可能会损害健康成年人的血糖控制并降低胰岛素敏感性。然而，表现出暴饮暴食行为的个体在短得多的时间内就会过度进食；这种行为的代谢后果尚不清楚。本研究的目的是确定单日高脂过量喂养对全身胰岛素敏感性的影响。15名年轻健康的成年人在食用一天高脂（占总能量的68%）、高能量（比每日需求量高78%）饮食前后进行了口服葡萄糖耐量试验。测量了空腹和餐后血浆中的葡萄糖、胰岛素、非酯化脂肪酸和甘油三酯浓度，并计算了松田胰岛素敏感性指数。单日高脂过量喂养使餐后葡萄糖曲线下面积（AUC）增加了17.1%（<0.0001），胰岛素AUC增加了16.4%（=0.007）。全身胰岛素敏感性下降了28%（=0.001）。总之，单日高脂过量喂养损害了年轻健康成年人的全身胰岛素敏感性。这突出了通过高脂食物过量摄入卡路里会多快地损害葡萄糖代谢，并表明急性暴饮暴食可能会对个体产生直接的代谢健康后果。
