Alexanderson Helene, Bergegård Jenny, Björnådal Lena, Nordin Annica
Department of Neurobiology, Care Science and Society, Division of Physical Therapy, Karolinska Institutet, Stockholm, Sweden.
BMC Res Notes. 2014 Feb 7;7:86. doi: 10.1186/1756-0500-7-86.
No previous studies have examined the effect of intensive exercise in systemic sclerosis patients with pulmonary impairment. The objective of this study was to examine the effect of an eight-week intensive aerobic exercise and muscle endurance training program for patients with systemic sclerosis with 50-100% of forced vital capacity.
A single-subject experimental design with repeated systematic measures during a six week A-phase (non-interventional baseline period) and an eight week B-phase (exercise intervention period) was used. Three women and one man with median age 66 years and median disease duration of 3.5 years completed aerobic exercise corresponding to 15 on the Borg RPE scale (strenuous) and muscular endurance training three times/week. Physical capacity (six-minute walk test), aerobic capacity (submaximal treadmill test) and muscle endurance in shoulder and hip flexion (Functional Index 2) were assessed every other week throughout the 14-week study. Activity limitation (Health Assessment Questionnaire), quality of life (Short Form 36), Raynaud, Fatigue and Global Health during the recent week (Visual Analogue Scales) were assessed at weeks 0, 6, 14.
Three participants improved significantly in muscular endurance, and two participants improved significantly or clinically relevant in aerobic capacity. All other variables remained unchanged, except for a trend towards reduced fatigue.
This eight week exercise program was largely successful with positive effects on aerobic capacity and muscle endurance.
Clinicaltrials.gov Identifier: NCT01813578.
既往尚无研究探讨强化运动对合并肺部损害的系统性硬化症患者的影响。本研究的目的是探讨为期八周的强化有氧运动和肌肉耐力训练计划对用力肺活量为50%-100%的系统性硬化症患者的影响。
采用单受试者实验设计，在为期六周的A期（非干预基线期）和为期八周的B期（运动干预期）进行重复系统测量。三名女性和一名男性，中位年龄66岁，中位病程3.5年，完成了相当于Borg RPE量表上15级（剧烈）的有氧运动和每周三次的肌肉耐力训练。在为期14周的研究中，每隔一周评估一次身体能力（六分钟步行试验）、有氧能力（次极量跑步机试验）以及肩部和髋部屈曲的肌肉耐力（功能指数2）。在第0、6、14周评估活动受限情况（健康评估问卷）、生活质量（简明健康调查问卷36项）、雷诺现象、疲劳以及最近一周的整体健康状况（视觉模拟量表）。
三名参与者的肌肉耐力显著改善，两名参与者的有氧能力有显著或临床相关改善。所有其他变量均保持不变，但疲劳有减轻趋势。
这项为期八周的运动计划在很大程度上取得了成功，对有氧能力和肌肉耐力有积极影响。
Clinicaltrials.gov标识符：NCT01813578。
