Departamento de Bioquímica, Universidade Estadual de Campinas (UNICAMP), Campus Universitário Zeferino Vaz, s/n, Cidade Universitária, CEP 13083-870 Campinas, SP, Brazil.
Departamento de Engenharia Ambiental, Universidade Estadual Paulista (UNESP) , Avenida Três de Março, 511, CEP 18087-180 Sorocaba, SP, Brazil.
J Hazard Mater. 2014 Mar 15;268:207-15. doi: 10.1016/j.jhazmat.2014.01.025. Epub 2014 Jan 24.
Nanoparticles of poly(epsilon-caprolactone) containing the herbicide atrazine were prepared, characterized, and evaluated in terms of their herbicidal activity and genotoxicity. The stability of the nanoparticles was evaluated over a period of three months, considering the variables: size, polydispersion index, pH, and encapsulation efficiency. Tests on plants were performed with target (Brassica sp.) and non-target (Zea mays) organisms, and the nanoparticle formulations were shown to be effective for the control of the target species. Experiments using soil columns revealed that the use of nanoparticles reduced the mobility of atrazine in the soil. Application of the Allium cepa chromosome aberration assay demonstrated that the nanoparticle systems were able to reduce the genotoxicity of the herbicide. The formulations developed offer a useful means of controlling agricultural weeds, while at the same time reducing the risk of harm to the environment and human health.
制备了含有除草剂莠去津的聚己内酯纳米粒子，并对其进行了表征，从除草活性和遗传毒性方面进行了评价。在三个月的时间内，通过考察粒径、多分散指数、pH 值和包封率等变量，评估了纳米粒子的稳定性。在目标（芸薹属）和非目标（玉米）生物上进行了植物试验，结果表明纳米粒子配方对目标物种的控制有效。使用土壤柱的实验表明，纳米粒子的使用降低了莠去津在土壤中的迁移性。采用洋葱染色体畸变试验证明，纳米粒子体系能够降低除草剂的遗传毒性。所开发的制剂为控制农业杂草提供了一种有用的手段，同时降低了对环境和人类健康造成危害的风险。
