MD MS, Department of Neurosurgery, PO Box 100265, Gainesville, FL 32610, U.S.A.
Anticancer Res. 2014 Feb;34(2):565-74.
In 1891, an orthopedic surgeon in New York noted the disappearance of an inoperable sarcoma in a patient after a febrile illness. This observation resulted in experiments assessing the utility of heat therapy or thermotherapy for the treatment of cancer. While it initially fell from favor, thermotherapy has recently made a resurgence, sparking investigations into its anticancer properties. This therapy is especially attractive for glioblastoma multiforme (GBM) which is difficult to target due to the blood-brain barrier and recalcitrant to treatment. Here we briefly review the history of thermotherapy and then more methodically present the current literature as it relates to central nervous system malignancies. Recent developments show that heat is preferentially cytotoxic to tumor cells and induces cellular pathways which result in apoptotic and non-apoptotic death. Techniques to induce hyperthermia include regional hyperthermia by water bath, focused ultrasound, radiofrequency microwaves, laser-induced interstitial thermotherapy, and magnetic energy. The recent revival of these therapeutic approaches and their preliminary outcomes in the treatment of GBM is reviewed. From bacterial toxins to infusion of magnetic nanoparticles, hyperthermia has the potential to be an effective and easy-to-execute adjuvant therapy for GBM. Hyperthermia for GBM is a promising therapy as part of a growing armamentarium for malignant glioma treatment.
1891 年，纽约的一位矫形外科医生注意到一名患有发热性疾病的无法手术的肉瘤患者的肿瘤消失了。这一观察结果促使人们进行了评估热疗或热疗法治疗癌症的效用的实验。虽然它最初失宠，但热疗最近又重新兴起，引发了对其抗癌特性的研究。这种疗法对多形性胶质母细胞瘤（GBM）特别有吸引力，因为血脑屏障的存在使 GBM 难以靶向，而且对治疗有抗性。在这里，我们简要回顾一下热疗的历史，然后更系统地介绍与中枢神经系统恶性肿瘤相关的当前文献。最近的发展表明，热量对肿瘤细胞具有优先的细胞毒性，并诱导导致细胞凋亡和非细胞凋亡死亡的细胞途径。诱导高热的技术包括水浴局部热疗、聚焦超声、射频微波、激光间质热疗和磁能。我们回顾了这些治疗方法在治疗 GBM 中的最新进展及其初步结果。从细菌毒素到输注磁性纳米颗粒，热疗有可能成为 GBM 的一种有效且易于实施的辅助治疗方法。作为恶性神经胶质瘤治疗手段不断增加的一部分，GBM 的热疗是一种很有前途的治疗方法。
