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一生中的外阴皮肤疾病:关于一些典型的皮肤病

Vulvar skin disorders throughout lifetime: about some representative dermatoses.

作者信息

Doyen Jean, Demoulin Stéphanie, Delbecque Katty, Goffin Frédéric, Kridelka Frédéric, Delvenne Philippe

机构信息

Department of Gynecology and Obstetrics, Regional Hospital Citadelle, 4000 Liege, Belgium.

Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, 4000 Liege, Belgium.

出版信息

Biomed Res Int. 2014;2014:595286. doi: 10.1155/2014/595286. Epub 2014 Jan 8.

DOI:10.1155/2014/595286
PMID:24511539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3910662/
Abstract

The objective of this paper is to present general considerations which should be kept in mind by clinicians in charge of women with vulvar diseases. Four representative vulvar dermatoses are described. Lichen simplex chronicus is a pathological condition related to chemical and mechanical irritant agents. Detrimental effects of these irritants, in the presence of other dermatoses, have to be considered when therapeutic responses are unsatisfactory. Lichen sclerosus is the most common vulvar dermatosis in elderly. However, it should be kept in mind that it may be diagnosed at any age. Lichen planus, in spite of sharing a similar range of etiological factors with lichen sclerosus, is a very distinct entity. Finally, Paget's disease, although rare, is also described especially because of the challenge it represents both clinically and therapeutically.

摘要

本文的目的是提出负责外阴疾病女性患者的临床医生应牢记的一般注意事项。描述了四种具有代表性的外阴皮肤病。慢性单纯性苔藓是一种与化学和机械性刺激物相关的病理状况。当治疗反应不令人满意时,在存在其他皮肤病的情况下,必须考虑这些刺激物的有害影响。硬化性苔藓是老年人中最常见的外阴皮肤病。然而,应记住它可在任何年龄被诊断出来。扁平苔藓尽管与硬化性苔藓有一系列相似的病因,但却是一种非常不同的疾病。最后,佩吉特病尽管罕见,但也进行了描述,特别是因为它在临床和治疗方面都带来了挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94b/3910662/d139bad26229/BMRI2014-595286.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94b/3910662/e4a81404efeb/BMRI2014-595286.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94b/3910662/68ea3747ed18/BMRI2014-595286.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94b/3910662/d139bad26229/BMRI2014-595286.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94b/3910662/e4a81404efeb/BMRI2014-595286.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94b/3910662/68ea3747ed18/BMRI2014-595286.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94b/3910662/d139bad26229/BMRI2014-595286.003.jpg

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本文引用的文献

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Imiquimod therapy for extramammary Paget's disease of the vulva: a viable non-surgical alternative.咪喹莫特治疗外阴部乳房外佩吉特病:一种可行的非手术替代方案。
J Obstet Gynaecol. 2013 Jul;33(5):479-83. doi: 10.3109/01443615.2013.790348.
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Topical calcineurin inhibitors and lymphoma risk: evidence update with implications for daily practice.局部钙调磷酸酶抑制剂与淋巴瘤风险:更新证据及其对日常实践的影响。
Am J Clin Dermatol. 2013 Jun;14(3):163-78. doi: 10.1007/s40257-013-0020-1.
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Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise.
An Bras Dermatol. 2018 Mar;93(2):294-296. doi: 10.1590/abd1806-4841.20186784.
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Vulvar Dermatoses: A Review and Update.外阴皮肤病:综述与更新
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外阴部糜烂性扁平苔藓的诊断标准:一项国际电子德尔菲共识研究。
Br J Dermatol. 2013 Aug;169(2):337-43. doi: 10.1111/bjd.12334.
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Diagnosis and treatment of lichen sclerosus: an update.硬化性苔藓的诊断与治疗:最新进展。
Am J Clin Dermatol. 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4.
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Hypertrophic lichen sclerosus with dyskeratosis and parakeratosis--a common presentation of vulvar lichen sclerosus not associated with a significant risk of malignancy.
Am J Dermatopathol. 2013 Oct;35(7):713-21. doi: 10.1097/DAD.0b013e31827e7ea9.
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