Department of Bioengineering, University of California, Berkeley , Berkeley, California 94720, United States.
Langmuir. 2014 Mar 4;30(8):2223-9. doi: 10.1021/la404333b. Epub 2014 Feb 19.
Graphene-based materials commonly require functionalization for biological applications in order to control their physical/colloidal properties and to introduce additional capabilities, such as stimuli-responsiveness and affinity to specific biomolecules. Here, we functionalized CVD-grown graphene and graphene oxide with a genetically engineered elastin-like polypeptide fused to a graphene binding peptide and then showed that the resulting hybrid materials exhibit thermo- and photoresponsive behaviors. Furthermore, we demonstrate that our genetic engineering strategy allows for the facile introduction of bioactivity to reduced graphene oxide. The stimuli-responsiveness and genetic tunability of our graphene-protein nanocomposites are attractive for addressing future biomedical applications.
基于石墨烯的材料通常需要功能化才能用于生物应用，以控制其物理/胶体性质并引入额外的功能，例如刺激响应性和对特定生物分子的亲和力。在这里，我们用一种与石墨烯结合肽融合的基因工程弹性蛋白样多肽对 CVD 生长的石墨烯和氧化石墨烯进行了功能化，然后表明所得的混合材料表现出热响应和光响应行为。此外，我们证明我们的基因工程策略允许轻松地将生物活性引入还原氧化石墨烯。我们的石墨烯-蛋白质纳米复合材料的刺激响应性和遗传可调性对于解决未来的生物医学应用具有吸引力。
