人类免疫缺陷病毒在人脑细胞中的复制。简要报告。
Human immunodeficiency virus replication in human brain cells. Brief report.
作者信息
Srinivasan A, Dorsett D, York D, Bohan C, Anand R
机构信息
Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, Georgia.
出版信息
Arch Virol. 1988;99(1-2):135-41. doi: 10.1007/BF01311031.
PMID:2451491
Abstract
Human immunodeficiency virus (HIV), the etiologic agent of AIDS, was found to infect and replicate in human brain cells. The extent of HIV replication was minimal in human brain-derived cells in comparison to T4 lymphoid cells. These results suggest that direct infection of glial/neuronal cells by HIV may contribute to the CNS dysfunction frequently observed in HIV infected individuals.
摘要
人类免疫缺陷病毒（HIV）是艾滋病的病原体，已发现它可在人脑细胞中感染并复制。与T4淋巴细胞相比，HIV在人脑来源细胞中的复制程度很低。这些结果表明，HIV对神经胶质细胞/神经元细胞的直接感染可能导致HIV感染者中经常观察到的中枢神经系统功能障碍。
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