Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Gut Liver. 2014 Jan;8(1):35-40. doi: 10.5009/gnl.2014.8.1.35. Epub 2013 Nov 5.
BACKGROUND/AIMS: The most common cause of chronic periodontitis is poor oral hygiene. Gastroesophageal reflux disease (GERD) enhances the proximal migration of gastric contents and may cause poor oral hygiene. We hypothesized that GERD may increase the risk of chronic periodontitis and investigated this potential relationship.
A retrospective cross-sectional study was conducted in outpatients between January 1, 2010, and April 30, 2012. GERD was defined as being present based on at least two of the following criteria: etiologic agent(s), identifiable signs and symptoms, and consistent anatomic alterations. A total of 280 patients with chronic periodontitis and 280 controls were analyzed. Information regarding patient demographics and other potential confounding factors for chronic periodontitis were collected through individual medical records.
GERD was revealed to be independently associated with an increased incidence of chronic periodontitis (odds ratio [OR], 2.883; 95% confidence interval [CI], 1.775 to 4.682). The other three variables of dental caries (OR, 1.531; 95% CI, 1.042 to 2.249), tobacco use (OR, 2.335; 95% CI, 1.461 to 3.730), and history of medication (calcium channel blocker, cyclosporine, or phenytoin) (OR, 2.114; 95% CI, 1.160 to 3.854) were also determined to be independent risk factors.
The present study supported our hypothesis that GERD can be a risk factor for chronic periodontitis.
背景/目的：慢性牙周炎最常见的病因是口腔卫生不良。胃食管反流病（GERD）会增强胃内容物的近端迁移，可能导致口腔卫生不良。我们假设 GERD 可能会增加慢性牙周炎的风险，并对此潜在关系进行了研究。
这是一项于 2010 年 1 月 1 日至 2012 年 4 月 30 日在门诊进行的回顾性病例对照研究。GERD 的定义为至少符合以下两个标准：病因、可识别的体征和症状以及一致的解剖学改变。共分析了 280 例慢性牙周炎患者和 280 例对照者。通过个人病历收集了患者人口统计学资料和其他可能导致慢性牙周炎的潜在混杂因素信息。
结果显示，GERD 与慢性牙周炎的发生独立相关（比值比 [OR]，2.883；95%置信区间 [CI]，1.775 至 4.682）。其他三个变量龋齿（OR，1.531；95% CI，1.042 至 2.249）、吸烟（OR，2.335；95% CI，1.461 至 3.730）和用药史（钙通道阻滞剂、环孢素或苯妥英）（OR，2.114；95% CI，1.160 至 3.854）也被确定为独立的危险因素。
本研究支持了我们的假设，即 GERD 可能是慢性牙周炎的一个危险因素。
