Terauchi Masakazu, Horiguchi Noe, Kajiyama Asuka, Akiyoshi Mihoko, Owa Yoko, Kato Kiyoko, Kubota Toshiro
From the Departments of 1Women's Health and 2Obstetrics and Gynecology, Tokyo Medical and Dental University, Tokyo, Japan.
Menopause. 2014 Sep;21(9):990-6. doi: 10.1097/GME.0000000000000200.
This study aims to assess the effects of proanthocyanidin-a class of polyphenol antioxidants extracted from grape seeds-on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women.
We conducted a randomized, double-blind, placebo-controlled study in 96 women aged 40 to 60 years who had at least one menopausal symptom. The study participants were randomized to receive grape seed extract tablets containing either low-dose (100 mg/d) or high-dose (200 mg/d) proanthocyanidin, or placebo, for 8 weeks. Their menopausal symptoms were evaluated using the Menopausal Health-Related Quality of Life Questionnaire, Hospital Anxiety and Depression Scale, and Athens Insomnia Scale before and after 4 and 8 weeks of treatment. Body composition and cardiovascular parameters were also measured.
A total of 91 women (95%) completed the study. Background characteristics, including age, menopause status, subjective symptom scores, body composition, and cardiovascular parameters, were similar among the groups. The following significant changes were observed during the course of the study: (1) physical symptom score, hot flash score, and (2) Athens Insomnia Scale score decreased in the high-dose group after 8 weeks of treatment; (3) Hospital Anxiety and Depression Scale Anxiety score and (4) systolic and diastolic blood pressure decreased in the low-dose and high-dose groups after 4 weeks; and, (5) lastly, muscle mass increased in the low-dose and high-dose groups after 8 weeks of treatment.
Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure in middle-aged women.
本研究旨在评估原花青素（一种从葡萄籽中提取的多酚类抗氧化剂）对中年女性更年期症状、身体成分和心血管参数的影响。
我们对96名年龄在40至60岁、至少有一项更年期症状的女性进行了一项随机、双盲、安慰剂对照研究。研究参与者被随机分为三组，分别接受含低剂量（100毫克/天）或高剂量（200毫克/天）原花青素的葡萄籽提取物片，或安慰剂，为期8周。在治疗4周和8周前后，使用更年期健康相关生活质量问卷、医院焦虑抑郁量表和雅典失眠量表对她们的更年期症状进行评估。同时还测量了身体成分和心血管参数。
共有91名女性（95%）完成了研究。各组之间的背景特征，包括年龄、绝经状态、主观症状评分、身体成分和心血管参数相似。在研究过程中观察到以下显著变化：（1）高剂量组在治疗8周后，身体症状评分、潮热评分降低；（2）高剂量组在治疗8周后，雅典失眠量表评分降低；（3）低剂量组和高剂量组在治疗4周后，医院焦虑抑郁量表焦虑评分降低；（4）低剂量组和高剂量组在治疗4周后，收缩压和舒张压降低；（5）低剂量组和高剂量组在治疗8周后，肌肉量增加。
葡萄籽原花青素提取物在改善中年女性更年期的身体和心理症状、增加肌肉量和降低血压方面有效。
