Zagzag D, Goldenberg M, Brem S
Department of Neurosciences, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
AJR Am J Roentgenol. 1989 Jul;153(1):141-6. doi: 10.2214/ajr.153.1.141.
Because of the crucial role played by tumor neovascularization in contrast enhancement, we studied the CT imaging findings in a transplantable rabbit brain tumor, the VX2 carcinoma that induces angiogenesis and the breakdown of blood-brain barrier associated with contrast enhancement. Tumor detection by contrast enhancement followed the peak of angiogenesis. Inhibition of angiogenesis, by copper depletion and penicillamine, led to avascular tumors that lack contrast enhancement. Furthermore, there was no contrast enhancement in brain adjacent to the tumor of normocupremic rabbits or within the hypocupremic tumor, despite the breakdown of the blood-brain barrier, without the concomitant presence of angiogenesis. We conclude that contrast enhancement of intracranial tumors is dependent primarily on the proliferation of the microvasculature.
由于肿瘤新生血管化在对比增强中发挥着关键作用，我们研究了可移植兔脑肿瘤VX2癌的CT成像表现，该肿瘤可诱导血管生成以及与对比增强相关的血脑屏障破坏。通过对比增强进行肿瘤检测是在血管生成高峰之后。通过铜缺乏和青霉胺抑制血管生成会导致无血管肿瘤，缺乏对比增强。此外，尽管血脑屏障遭到破坏，但在正常血铜兔肿瘤附近的脑内或低血铜肿瘤内，在没有伴随血管生成的情况下，没有对比增强。我们得出结论，颅内肿瘤的对比增强主要取决于微血管系统的增殖。
