Egawa Mariko, Mitamura Yoshinori, Hayashi Yuki, Naito Takeshi
Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
Clin Ophthalmol. 2014 Jan 31;8:335-41. doi: 10.2147/OPTH.S58114. eCollection 2014.
The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in three eyes with primary intraocular lymphoma (PIOL).
The medical records of three eyes from three patients with biopsy-proven PIOL and retinal infiltrations were reviewed. The SD-OCT and fluorescein angiographic findings were evaluated in the three eyes and FAF images in two eyes.
The PIOL in the three patients was monocular. Vitreous opacities and retinal infiltrations were observed in the three eyes, and iritis was present in two eyes. The cytologic diagnosis was class V in two eyes and class III in one eye. The interleukin-10/interleukin-6 ratio was >1.0 in the vitreous and aqueous humor of the three eyes. The FAF images for two eyes showed abnormal granular hyperautofluorescence and hypoautofluorescence which were the reverse of the pattern in the fluorescein angiographic images. In all three eyes, SD-OCT showed hyper-reflective infiltrations at the level of the retinal pigment epithelium (RPE), a separation of the Bruch membrane from the RPE, damage to the RPE, disruption of the photoreceptor inner segment/outer segment junction, and multiple hyper-reflective signals in the inner retina.
Because of the characteristic FAF and SD-OCT findings in these eyes with PIOL, we suggest that these noninvasive methods may be used for a rapid diagnosis of PIOL and also for understanding the pathology of PIOL.
本研究旨在评估原发性眼内淋巴瘤（PIOL）患者三只眼中的频域光学相干断层扫描（SD-OCT）和眼底自发荧光（FAF）检查结果。
回顾了三名经活检证实患有PIOL且伴有视网膜浸润的患者的三只眼的病历。对这三只眼的SD-OCT和荧光素血管造影检查结果进行了评估，并对其中两只眼进行了FAF图像分析。
三名患者的PIOL均为单眼发病。三只眼中均观察到玻璃体混浊和视网膜浸润，两只眼中存在虹膜炎。细胞学诊断为两只眼为V级，一只眼为III级。三只眼的玻璃体和房水中白细胞介素-10/白细胞介素-6比值均>1.0。两只眼的FAF图像显示异常的颗粒状高自发荧光和低自发荧光，与荧光素血管造影图像的表现相反。在所有三只眼中，SD-OCT均显示视网膜色素上皮（RPE）层有高反射性浸润、Bruch膜与RPE分离、RPE损伤、光感受器内段/外段连接破坏以及视网膜内层有多个高反射信号。
鉴于这些PIOL患眼中FAF和SD-OCT的特征性表现，我们认为这些非侵入性方法可用于PIOL的快速诊断以及了解PIOL的病理情况。
