Wang Jiao, Jiang Yang-Fu
Jiao Wang, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
World J Exp Med. 2012 Jun 20;2(3):45-57. doi: 10.5493/wjem.v2.i3.45.
Cancer prevention research has drawn much attention worldwide. It is believed that some types of cancer can be prevented by following a healthy life style. Cancer chemoprevention by either natural or synthetic agents is a promising route towards lowering cancer incidence. In recent years, the concept of cancer chemoprevention has evolved greatly. Experimental studies in animal models demonstrate that the reversal or suppression of premalignant lesions by chemopreventive agents is achievable. Natural occurring agents such as dietary phytochemicals, tea polyphenols and resveratrol show chemopreventive activity in animal models. Moreover, clinical trials for testing the safety and efficacy of a variety of natural agents in preventing or treating human malignancy have been ongoing. Here, we summarize experimental data on the chemopreventive or tumor suppressive effects of several natural compounds including curcumin, (-)-epigallocatechin-3-gallate, resveratrol, indole-3-carbinol, and vitamin D.
癌症预防研究在全球范围内备受关注。人们认为，遵循健康的生活方式可以预防某些类型的癌症。通过天然或合成药物进行癌症化学预防是降低癌症发病率的一条有前景的途径。近年来，癌症化学预防的概念有了很大的发展。在动物模型中的实验研究表明，化学预防剂可以逆转或抑制癌前病变。天然存在的物质，如膳食植物化学物质、茶多酚和白藜芦醇，在动物模型中显示出化学预防活性。此外，测试各种天然药物预防或治疗人类恶性肿瘤的安全性和有效性的临床试验也在进行中。在此，我们总结了几种天然化合物，包括姜黄素、（-）-表没食子儿茶素-3-没食子酸酯、白藜芦醇、吲哚-3-甲醇和维生素D的化学预防或肿瘤抑制作用的实验数据。
