Hagedorn Theresa, Poggiogalle Eleonora, Savina Claudia, Coletti Cecilia, Paolini Maddalena, Scavone Luciano, Neri Barbara, Donini Lorenzo Maria
Theresa Hagedorn, Claudia Savina, Cecilia Coletti, Maddalena Paolini, Luciano Scavone, Rehabilitation Clinical Institute "Villa delle Querce", Nemi, 00040 Rome, Italy.
World J Exp Med. 2012 Jun 20;2(3):58-64. doi: 10.5493/wjem.v2.i3.58.
To evaluate selected factors influencing resting energy expenditure (REE) in obese female subjects.
Seventy seven 61 obese Caucasian women [mean age of 52.93 ± 13.45 years, and mean body mass index (BMI) of 41.78 ± 11.54 kg/m(2)] were enrolled; measurements of resting metabolic rate (RMR) by a ventilated, open-circuit system, indirect calorimeter were performed after an overnight fast. Body composition as well as medications, physical parameters, blood samples, disease pattern, and smoking were considered.
RMR was significantly associated with body weight (r = 0.732, P < 0.001), body height (r = 0.401, P = 0.008), BMI (r = 0.504, P < 0.001), waist circumference (r = 0.602, P < 0.001), mid-upper arm circumference (r = 0.417, P = 0.006), mid-upper arm muscle circumference (r = 0.344, P = 0.028), total body water (r = 0.339, P = 0.035), body temperature (r = 0.409, P = 0.007), smoking (P = 0.031), serum T4 levels (r = 0.331, P = 0.036), obstructive sleep apnoea syndrome (OSAS; P = 0.023), impaired glucose tolerance (IGT; P = 0.017) and impaired glycaemic status, including hyperinsulinism, IGT and diabetes mellitus (P = 0.003).
Future research should be prompted to optimize the procedure of indirect calorimetry to achieve clinical benefits in obese subjects.
评估影响肥胖女性受试者静息能量消耗（REE）的选定因素。
招募了77名61岁的肥胖白种女性[平均年龄52.93±13.45岁，平均体重指数（BMI）为41.78±11.54kg/m²]；在禁食过夜后，通过通风开路系统间接热量计测量静息代谢率（RMR）。考虑了身体成分以及药物、身体参数、血液样本、疾病模式和吸烟情况。
RMR与体重（r = 0.732，P < 0.001）、身高（r = 0.401，P = 0.008）、BMI（r = 0.504，P < 0.001）、腰围（r = 0.602，P < 0.001）、上臂中部周长（r = 0.417，P = 0.006）、上臂中部肌肉周长（r = 0.344，P = 0.028）、全身水含量（r = 0.339，P = 0.035）、体温（r = 0.409，P = 0.007）、吸烟（P = 0.031）、血清T4水平（r = 0.331，P = 0.036）、阻塞性睡眠呼吸暂停综合征（OSAS；P = 0.023）、糖耐量受损（IGT；P = 0.017）以及包括高胰岛素血症、IGT和糖尿病在内的血糖状态受损（P = 0.003）显著相关。
应推动未来的研究优化间接量热法的程序，以在肥胖受试者中实现临床益处。
