Tan Nguan S, Wahli Walter
School of Biological Sciences Nanyang Technological University, Singapore City, Singapore.
EMBO Mol Med. 2014 Apr;6(4):431-3. doi: 10.1002/emmm.201303797. Epub 2014 Feb 12.
The nuclear factor erythroid 2-related factor 2 (Nrf2) is best known for its role in resistance to oxidant stress. In this issue of EMBO Molecular Medicine, Nrf2-prolonged genetic activation is shown with devastating effects on skin homeostasis. The study provides novel molecular insights into poison-induced chloracne and metabolizing acquired dioxin-induced skin hamartomas or MADISH.
核因子红细胞2相关因子2（Nrf2）因其在抵抗氧化应激中的作用而最为人所知。在本期《EMBO分子医学》中，Nrf2的长期基因激活显示出对皮肤稳态具有毁灭性影响。该研究为毒物诱导的氯痤疮以及代谢性获得性二噁英诱导的皮肤错构瘤或MADISH提供了新的分子见解。
