幽门螺杆菌感染与糖尿病患者血糖控制的关联：一项荟萃分析。
Association of Helicobacter pylori infection with glycemic control in patients with diabetes: a meta-analysis.
作者信息
Horikawa Chika, Kodama Satoru, Fujihara Kazuya, Yachi Yoko, Tanaka Shiro, Suzuki Akiko, Hanyu Osamu, Shimano Hitoshi, Sone Hirohito
机构信息
Department of Health and Nutrition, Faculty of Human Life Studies, University of Niigata Prefecture, Niigata, Japan ; Department of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, Japan ; Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Department of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, Japan ; Department of Health Management Center, Mito Kyodo General Hospital, Ibaraki, Japan.
出版信息
J Diabetes Res. 2014;2014:250620. doi: 10.1155/2014/250620. Epub 2014 May 8.
OBJECTIVE. To assess the association between Helicobacter pylori (HP) infection and glycemic control in patients with diabetes through a meta-analytic approach. RESEARCH DESIGN AND METHODS. Electronic literature searches were conducted for cross-sectional studies that examined the hemoglobin A1c (A1C) level by whether patients with diabetes were or were not carriers of HP. Mean differences in A1C between groups with and without HP infection were pooled with a random-effects model. RESULTS. Thirteen eligible studies were included in this meta-analysis. Overall, the HP carriers did not have significantly higher A1C levels compared with HP noncarriers (mean difference (95% CI), 0.19% (-0.18 to 0.46), P = 0.16). When the analysis was limited to studies targeting patients with type 1 diabetes, there was also no significant difference in A1C (0.69% (-0.31 to 1.68), P = 0.18). CONCLUSIONS. There was insufficient evidence that HP infection worsened glycemic control in patients with diabetes.
目的。通过荟萃分析方法评估糖尿病患者中幽门螺杆菌（HP）感染与血糖控制之间的关联。研究设计与方法。对横断面研究进行电子文献检索，这些研究根据糖尿病患者是否为HP携带者来检测糖化血红蛋白（A1C）水平。采用随机效应模型汇总HP感染组和未感染组之间A1C的平均差异。结果。本荟萃分析纳入了13项符合条件的研究。总体而言，与非HP携带者相比，HP携带者的A1C水平没有显著升高（平均差异（95%CI），0.19%（-0.18至0.46），P = 0.16）。当分析仅限于针对1型糖尿病患者的研究时，A1C也没有显著差异（0.69%（-0.31至1.68），P = 0.18）。结论。没有足够的证据表明HP感染会使糖尿病患者的血糖控制恶化。
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