Ceylan Emel, Doruk Sibel, Genc Sebahat, Ozkutuk Ayşe Aydan, Karadag Fisun, Ergor Gul, Itil Bahriye Oya, Cımrın Arif Hikmet
Department of Pulmonary Medicine, Adnan Menderes University, Aydın, Turkey.
Department of Pulmonary Medicine, Gaziosmanpasa University, Tokat, Turkey.
J Res Med Sci. 2013 Dec;18(12):1067-73.
The effect of mold fungi to allergic sensitization is not well-known. We aimed to evaluate the role of molds in the relation between indoor environment and atopy in asthmatics.
The air samples obtained from 66 stable asthmatics and 35 control subject's houses were sprayed into Sabouraud dextrose agar. Allergy skin testing were performed in both groups. The temperature and humidity of each house were measured.
The incidence of atopy was similar in cases (59.1%) and controls (51.4%). The average amount of mold was 35.9 CFU/m(3) and 34.3 CFU/m(3), respectively. The number of household residents was positively correlated with the amount of molds. There was no difference in the amount of mold with respect to dosage of inhaler corticosteroids as well as symptom levels in asthmatics. The most frequently encountered allergens were Dermatophagoides farinae/Dermatophagoides pteronyssinus, grass/weeds and molds. Spending childhood in a village was more common among atopics.
Living environment during the childhood might affect atopy and asthma. Based on the identification of molds as the second most frequent allergen after mites in our study population, assessment of mold sensitization as well as in forming patients about ways to avoid them seem likely to contribute to the effective management of uncontrolled asthma.
霉菌对过敏致敏的影响尚不明确。我们旨在评估霉菌在哮喘患者室内环境与特应性之间关系中的作用。
从66名病情稳定的哮喘患者和35名对照者家中采集空气样本，接种于沙氏葡萄糖琼脂培养基上。两组均进行了变应原皮肤试验。测量了每户的温度和湿度。
特应性的发生率在病例组（59.1%）和对照组（51.4%）中相似。霉菌的平均含量分别为35.9 CFU/m³和34.3 CFU/m³。家庭居住人数与霉菌数量呈正相关。哮喘患者中，霉菌数量在吸入性糖皮质激素剂量以及症状水平方面并无差异。最常遇到的变应原是粉尘螨/屋尘螨、草/杂草和霉菌。特应性患者中在乡村度过童年更为常见。
童年时期的生活环境可能影响特应性和哮喘。基于在我们的研究人群中霉菌被鉴定为仅次于螨虫的第二常见变应原，评估霉菌致敏情况以及向患者介绍避免接触霉菌的方法似乎有助于有效管理控制不佳的哮喘。
