Yazicioglu M, Asan A, Ones U, Vatansever U, Sen B, Ture M, Bostancioglu M, Pala O
Department of Pediatrics, Trakya University Faculty of Medicine, Edirne, Turkey.
Allergol Immunopathol (Madr). 2004 Jul-Aug;32(4):197-203. doi: 10.1016/s0301-0546(04)79239-3.
The contribution of indoor fungal exposure to childhood asthma is not completely clear.
To investigate airborne fungal flora within the homes of asthmatic and control children, and to assess the influence of housing characteristics regarding indoor fungi.
Forty-seven atopic asthmatic and 23 nonatopic control children were studied. Allergen sensitivity was determined by skin prick tests. A thorough assessment, using a questionnaire and inspection surveys, was carried out. Home visits were made between October 2000 and February 2001. Samples of airborne fungal spores were collected from four rooms by the "open Petri dish" method. Indoor temperature and humidity were measured.
The total indoor fungal colony counts from the living rooms and bedrooms were significantly higher in the asthma group than in controls (p = .012 and p = .003, respectively). The most commonly isolated genus was Cladosporium. Twelve of the asthmatic patients (25.53 %) were found to be sensitive to fungal allergens. The factors found to be associated with indoor fungal growth in logistic regression were visible fungal patches in the bathrooms [(odds ratio (OR) = 5.75; 95 % CI 1.19 to 27.70)], and the age of the house [OR = 4.24; 95 % CI 1.34 to 13.45]. Total fungal colony numbers did not correlate with indoor temperature or humidity.
Fungal colony numbers were higher in the homes of asthmatic children than in those of controls. Therefore, indoor fungal exposure may contribute to childhood asthma. Bathrooms were the main source of fungal propagules. Old houses were more prone to fungal growth.
室内真菌暴露对儿童哮喘的影响尚不完全清楚。
调查哮喘儿童和对照儿童家中的空气传播真菌菌群，并评估房屋特征对室内真菌的影响。
对47名特应性哮喘儿童和23名非特应性对照儿童进行了研究。通过皮肤点刺试验确定过敏原敏感性。使用问卷和检查调查进行了全面评估。在2000年10月至2001年2月期间进行了家访。采用“开放培养皿”法从四个房间采集空气传播真菌孢子样本。测量了室内温度和湿度。
哮喘组客厅和卧室的室内真菌菌落总数显著高于对照组（分别为p = 0.012和p = 0.003）。最常见的分离菌属是枝孢菌属。发现12名哮喘患者（25.53%）对真菌过敏原敏感。逻辑回归分析发现与室内真菌生长相关的因素是浴室中可见的真菌斑块[比值比（OR）= 5.75；95%可信区间1.19至27.70]和房屋使用年限[OR = 4.24；95%可信区间1.34至13.45]。真菌菌落总数与室内温度或湿度无关。
哮喘儿童家中的真菌菌落数高于对照组。因此，室内真菌暴露可能导致儿童哮喘。浴室是真菌繁殖体的主要来源。老房子更容易滋生真菌。
