Duran Muzeyyen, Ustunyurt Emin, Kosus Aydin, Kosus Nermin, Turhan Nilgun, Hızlı Deniz, Sarac Gulce Naz, Erdogan Deniz
Sevket Yılmaz Education and Research Hospital, Department of Obs/Gyn, Bursa, Turkey.
Sevket Yılmaz Education and Research Hospital, Department of Obs/Gyn, Bursa, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2014 Apr;175:149-51. doi: 10.1016/j.ejogrb.2014.01.020. Epub 2014 Jan 28.
To assess the histomorphological effects of smoking on the cilia of fallopian tubes in mice and the effect of vitamin E on the negative effects of smoke.
Eighteen 12-14 week-old Swiss albino type female mice were randomly divided into three groups, each consisting of six mice: Group A: control group; Group B: mice exposed to cigarette smoke; Group C: mice exposed to cigarette smoke together with vitamin E. Groups B and C were exposed to cigarette smoke for 10 weeks. After 10 weeks, tubal excision was performed in all animals. Histopathologic examination of excised tubal tissue was conducted under light microscopy.
The number of cilia was significantly lower in Group B. Although not statistically significant, the median number of cilia in Group C was measured to be higher than in Group B but lower than in Group A.
Based on the results, it can be concluded that smoking decreases tubal cilia numbers. Supplementation by vitamin E may treat or at least help to slow down the decrease in number of cilia caused by smoking; therefore it could be used therapeutically in the treatment of smoking-related tubal damage.
评估吸烟对小鼠输卵管纤毛的组织形态学影响以及维生素E对吸烟负面影响的作用。
将18只12 - 14周龄的瑞士白化型雌性小鼠随机分为三组，每组6只：A组：对照组；B组：暴露于香烟烟雾的小鼠；C组：暴露于香烟烟雾并同时摄入维生素E的小鼠。B组和C组暴露于香烟烟雾10周。10周后，对所有动物进行输卵管切除。对切除的输卵管组织进行光镜下的组织病理学检查。
B组的纤毛数量显著减少。虽然无统计学意义，但C组的纤毛中位数高于B组但低于A组。
基于这些结果，可以得出结论，吸烟会减少输卵管纤毛数量。补充维生素E可能治疗或至少有助于减缓吸烟引起的纤毛数量减少；因此，它可用于治疗与吸烟相关的输卵管损伤。
