Stewart A, Hope P L, Hamilton P, Costello A M, Baudin J, Bradford B, Amiel-Tison C, Reynolds E O
Department of Paediatrics, University College, London.
Dev Med Child Neurol. 1988 Feb;30(1):53-63. doi: 10.1111/j.1469-8749.1988.tb04726.x.
This study was performed to find out how well ultrasound brain-scanning and neurological examination of very preterm infants, together and separately, predicted normal neurodevelopmental progress at 12 months corrected age. 111 infants born at less than 33 weeks gestation were scanned at discharge from the neonatal unit, and neurological examinations were performed at a gestation-equivalent age at or near term. During the first year of life repeated neurological and developmental testing was carried out. At 12 months a diagnosis of normal progress or of major or minor neurodevelopmental disorders was made. 56 (50 per cent) infants with both a favourable ultrasound scan and normal neurological findings had a 98 per cent (90 to 99 per cent) probability of normal progress at 12 months, and a 100 per cent (93 to 100 per cent) probability of having no major disorder. Separately, ultrasound scanning and neurological examination were not such good predictors of normal outcome, although they selected larger groups of infants with high probabilities of progressing normally. Ultrasound brain-scanning and neurological examination can be used in combination to identify potentially normal preterm infants when they are discharged to their homes.
本研究旨在探究对极早产儿进行超声脑部扫描和神经学检查，单独进行以及联合进行时，对其在矫正年龄12个月时神经发育正常进展的预测效果如何。111名孕周小于33周的婴儿在新生儿病房出院时接受了扫描，并在孕龄相当的足月或接近足月时进行了神经学检查。在生命的第一年进行了多次神经学和发育测试。在12个月时，对神经发育进展正常或患有严重或轻度神经发育障碍进行诊断。56名（50%）超声扫描结果良好且神经学检查正常的婴儿在12个月时神经发育正常进展的概率为98%（90%至99%），无严重障碍的概率为100%（93%至100%）。单独来看，超声扫描和神经学检查对正常结局的预测效果没那么好，尽管它们筛选出了更大组有正常进展高概率的婴儿。超声脑部扫描和神经学检查可以联合使用，以便在极早产儿出院回家时识别出可能神经发育正常的婴儿。
