aGI Unit, Glasgow Royal Infirmary bHealth Protection Scotland, Glasgow cGastroenterology Department, Ninewells Hospital, Dundee, Scotland dGastroenterology Department, Royal Cornwall Hospital, Truro, Cornwall eGastroenterology Department, North Tees University Hospital, Stockton-on-Tees, Cleveland, UK.
Eur J Gastroenterol Hepatol. 2014 Apr;26(4):432-7. doi: 10.1097/MEG.0000000000000051.
The Glasgow Blatchford score (GBS) is a pre-endoscopic risk assessment tool for patients presenting with upper gastrointestinal haemorrhage. There are few data regarding use in patients with variceal bleeding, who are generally accepted as being at high risk.
The aim of the study was to assess GBS in correctly identifying patients with subsequently proven variceal bleeding as 'high risk' and to compare GBS, admission and full Rockall scores in predicting clinical endpoints in this group.
Data on consecutive patients with upper gastrointestinal haemorrhage presenting to four UK hospitals were collected. The GBS, admission and full Rockall scores were calculated and compared for the subgroup subsequently shown to have variceal bleeding. Area under the receiver operating curve (AUROC) was used to assess the scores ability to predict clinical endpoints within this variceal bleeding subgroup.
A total of 1432 patients presented during the study period. Seventy-one (5%) had a final diagnosis of variceal bleeding. At presentation, none of this group had GBS less than 2, but six had an admission Rockall score of 0. In predicting need for blood transfusion, AUROC scores for GBS, full and admission Rockall scores were 0.68, 0.65 and 0.68, respectively. For endoscopic/surgical intervention the scores were 0.34, 0.51 and 0.55, respectively, and for predicting death the scores were 0.56, 0.72 and 0.70, respectively. None of these AUROC score comparisons were significant.
At presentation, GBS correctly identifies patients with variceal bleeding as high risk and appears superior to the admission Rockall score. However, GBS and both Rockall scores are poor at predicting clinical outcome within this group.
格拉斯哥 Blatchford 评分(GBS)是一种用于上消化道出血患者的内镜前风险评估工具。关于其在静脉曲张出血患者中的应用数据较少,一般认为这类患者风险较高。
本研究旨在评估 GBS 能否正确识别随后证实为静脉曲张出血的“高危”患者,并比较 GBS、入院时和完整 Rockall 评分在预测该组患者临床结局方面的作用。
收集了连续就诊于英国四家医院的上消化道出血患者的数据。计算了 GBS、入院时和完整 Rockall 评分,并对随后证实为静脉曲张出血的亚组进行比较。使用受试者工作特征曲线下面积(AUROC)评估评分预测该静脉曲张出血亚组临床结局的能力。
研究期间共有 1432 例患者就诊。71 例(5%)最终诊断为静脉曲张出血。就诊时,该组无一例 GBS 评分小于 2,但有 6 例入院时 Rockall 评分为 0。在预测输血需求方面,GBS、完整和入院时 Rockall 评分的 AUROC 评分分别为 0.68、0.65 和 0.68。对于内镜/手术干预,评分分别为 0.34、0.51 和 0.55,对于预测死亡,评分分别为 0.56、0.72 和 0.70。这些 AUROC 评分比较均无统计学意义。
就诊时,GBS 能正确识别静脉曲张出血患者为高危患者,且似乎优于入院时 Rockall 评分。然而,GBS 和两个 Rockall 评分在预测该组患者临床结局方面均表现不佳。