Desai K M, Abrams P H, White L O
Department of Urology, Southmead Hospital, Bristol, United Kingdom.
J Urol. 1988 Jun;139(6):1232-4. doi: 10.1016/s0022-5347(17)42875-8.
A double-blind randomized comparative study was done to investigate the efficacy of enoxacin in the prevention of urinary infection after elective transurethral prostatectomy, as well as its ability to penetrate the prostate. A total of 40 patients received 200 mg. enoxacin and 40 received a placebo, given orally the night before the operation, 2 to 4 hours preoperatively and every 12 hours postoperatively for 36 hours. Urine samples for bacterial culture were obtained within 1 week preoperatively, at operation and at 48 hours, 5 days, and 2 and 6 weeks postoperatively. Samples of the serum and prostate were taken at operation and assayed for enoxacin levels. Of the placebo patients 15 had a urinary infection postoperatively (38 per cent) compared to 3 enoxacin patients (8 per cent) (p less than 0.01). Enoxacin penetrated well into prostatic tissue; the mean levels in tissue and serum were 3.1 +/- 1.8 mg. per kg. (standard deviation) and 1.26 +/- 0.48 mg. per l., respectively, with a mean tissue-to-serum ratio of 2.53 +/- 1.8.
进行了一项双盲随机对照研究，以调查依诺沙星在择期经尿道前列腺切除术后预防尿路感染的疗效及其穿透前列腺的能力。共有40例患者接受200毫克依诺沙星，40例接受安慰剂，于手术前一晚、术前2至4小时及术后每12小时口服一次，共36小时。术前1周内、手术时以及术后48小时、5天、2周和6周采集尿液样本进行细菌培养。手术时采集血清和前列腺样本并检测依诺沙星水平。安慰剂组有15例患者术后发生尿路感染（38%），而依诺沙星组为3例（8%）（p<0.01）。依诺沙星能很好地穿透前列腺组织；组织和血清中的平均水平分别为每千克3.1±1.8毫克（标准差）和每升1.26±0.48毫克，组织与血清的平均比值为2.53±1.8。
