Amiot M, Dastot H, Degos L, Dausset J, Bernard A, Boumsell L
Institut National de la Santé et de la Recherche Médicale, Hôpital Saint-Louis, Paris, France.
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4451-4. doi: 10.1073/pnas.85.12.4451.
The molecules encoded by the major histocompatibility complex play a pivotal role in regulatory interactions between cells of the immune system, which can result in the activation and function of T cells. The function of the CD1 molecules, which are homologous to the major histocompatibility complex-encoded molecules but are encoded on human chromosome 1, is not known. HLA class I molecules and CD1a heavy chains share the ability to associate with several different cell-surface molecules. We show here, by several technical approaches, that HLA class I molecules are associated with CD1a heavy chains on the surface of normal thymus cells. The functional significance of this association during T-cell differentiation is discussed.
主要组织相容性复合体编码的分子在免疫系统细胞间的调节相互作用中起关键作用，这可能导致T细胞的激活和功能发挥。CD1分子与主要组织相容性复合体编码的分子同源，但由人类1号染色体编码，其功能尚不清楚。HLA I类分子和CD1a重链具有与几种不同细胞表面分子结合的能力。我们通过多种技术方法在此表明，HLA I类分子在正常胸腺细胞表面与CD1a重链相关联。本文讨论了这种关联在T细胞分化过程中的功能意义。
