Division of Neurology, Krembil Neuroscience Centre, University Health Network, University of Toronto Toronto, ON, Canada ; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto Toronto, ON, Canada ; Canadian Sports Concussion Project Toronto, ON, Canada.
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto Toronto, ON, Canada ; Canadian Sports Concussion Project Toronto, ON, Canada ; Department of Laboratory Medicine and Pathobiology, University of Toronto Toronto, ON, Canada.
Front Hum Neurosci. 2014 Jan 31;8:30. doi: 10.3389/fnhum.2014.00030. eCollection 2014.
"Chronic traumatic encephalopathy" (CTE) is described as a slowly progressive neurodegenerative disease believed to result from multiple concussions. Traditionally, concussions were considered benign events and although most people recover fully, about 10% develop a post-concussive syndrome with persisting neurological, cognitive and neuropsychiatric symptoms. CTE was once thought to be unique to boxers, but it has now been observed in many different athletes having suffered multiple concussions as well as in military personal after repeated blast injuries. Much remains unknown about the development of CTE but its pathological substrate is usually tau, similar to that seen in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). The aim of this "perspective" is to compare and contrast clinical and pathological CTE with the other neurodegenerative proteinopathies and highlight that there is an urgent need for understanding the relationship between concussion and the development of CTE as it may provide a window into the development of a proteinopathy and thus new avenues for treatment.
"慢性创伤性脑病"（CTE）被描述为一种缓慢进展的神经退行性疾病，据信是由多次脑震荡引起的。传统上，脑震荡被认为是良性事件，尽管大多数人完全康复，但约 10%的人会出现持续性神经、认知和神经精神症状的脑震荡后综合征。CTE 曾被认为是拳击手所特有的，但现在已经在许多遭受多次脑震荡的不同运动员以及多次爆炸伤后的军事人员中观察到。关于 CTE 的发展仍有许多未知，但它的病理底物通常是 tau，类似于阿尔茨海默病（AD）和额颞叶变性（FTLD）中所见。本“观点”的目的是比较和对比临床和病理 CTE 与其他神经退行性蛋白病，并强调迫切需要了解脑震荡与 CTE 发展之间的关系，因为这可能为蛋白病的发展提供一个窗口，从而为治疗提供新的途径。
