Laboratory of Biocompatibility, Innovative Technologies and Advanced Therapies, RIT-Rizzoli Orthopaedic Institute Bologna, Via Di Barbiano, 1/10, 40136, Bologna, Italy,
J Mater Sci Mater Med. 2014 Jun;25(6):1495-504. doi: 10.1007/s10856-014-5177-5. Epub 2014 Feb 20.
Despite several efforts to find suitable alternatives to autologous bone, no bone substitute currently available provides the same characteristics and properties. Nevertheless, among the wide range of materials proposed as bone substitutes, calcium phosphate materials represent the most promising category and the present study is aimed at improving the knowledge on non-stoichiometric magnesium-doped hydroxyapatite substitutes (Mg-HA), tested in two different formulations: Mg-HA Putty and Mg-HA Granules. These bone substitutes were implanted bilaterally into iliac crest bone defects in healthy sheep and comparative histological, histomorphometric, microhardness and ultrastructural assessments were performed 9, 12, 18 and 24 months after surgery to elucidate bone tissue apposition, mineralization and material degradation in vivo. The results confirmed that the biomimetic bone substitutes provide a histocompatible and osteoconductive structural support, during the bone formation process, and give essential information about the in vivo resorption process and biological behavior of biomimetic bone substitutes.
尽管已经做出了很多努力来寻找合适的自体骨替代品，但目前还没有一种骨替代物能够提供相同的特性和性能。然而，在作为骨替代物提出的广泛材料中，磷酸钙材料代表了最有前途的类别，本研究旨在提高对非化学计量镁掺杂羟基磷灰石替代物（Mg-HA）的认识，该替代物以两种不同的配方进行了测试：Mg-HA 油灰和 Mg-HA 颗粒。这些骨替代物被双侧植入健康绵羊的髂嵴骨缺损中，并在手术后 9、12、18 和 24 个月进行了比较组织学、组织形态计量学、显微硬度和超微结构评估，以阐明体内骨组织附着、矿化和材料降解。结果证实，仿生骨替代物在骨形成过程中提供了一种组织相容性和骨诱导性的结构支撑，并提供了关于仿生骨替代物体内吸收过程和生物学行为的重要信息。
