包膜抗体特异性不同，对感染性 HIV-1 病毒粒子的捕获能力也不同。
Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.
机构信息
Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA.
出版信息
J Virol. 2014 May;88(9):5165-70. doi: 10.1128/JVI.03765-13. Epub 2014 Feb 19.
Abstract
Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.
摘要
抗体识别感染性病毒的能力是许多抗病毒功能的前提。我们确定了不同抗体特异性的感染性病毒粒子捕获指数（IVCI）。虽然广泛中和抗体（bNAb）除了一个 MPER bNAb 外，选择性地捕获感染性病毒粒子，但非 bNAb 和黏膜人类免疫缺陷病毒 1（HIV-1）阳性 IgG 捕获了感染性和非感染性病毒粒子的亚群。感染性病毒粒子的捕获具有抗体混合物的加性，为疫苗诱导的抗体提供了概念验证，这些抗体共同具有提高识别感染性病毒粒子的能力。
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