伊朗青少年全国代表性样本中血清镁与维生素D水平的关系：CASPIAN-III研究
Relationship of Serum Magnesium and Vitamin D Levels in a Nationally-Representative Sample of Iranian Adolescents: The CASPIAN-III Study.
作者信息
Kelishadi Roya, Ataei Ehsan, Ardalan Gelayol, Nazemian Maryam, Tajadini Mohammadhasan, Heshmat Ramin, Keikha Mojtaba, Motlagh Mohammad Esmaeil
机构信息
Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of School Health, Bureau of Population, Family and School Health, Ministry of Health and Medical Education, Tehran, Iran.
出版信息
Int J Prev Med. 2014 Jan;5(1):99-103.
BACKGROUND
This study aims to assess the relationship of serum Mg and vitamin D levels in a nationally-representative sample of Iranian adolescents.
METHODS
The study participants consisted of 330 students, aged range from 10 to 18 years, consisting of an equal number of individuals with and without hypovitaminosis D. The correlation between serum 25 hydroxy vitamin D (25(OH) D) and magnesium (Mg) concentrations was determined.
RESULTS
The mean age of participants was 14.74 ± 2.587 years, without significant difference between those with hypovitaminosis D and those without it. The mean 25(OH) D level was 6.34 ± 1.47 ng/ml in the group with hypovitaminosis D and 39.27 ± 6.42 ng/ml in the group without it. The mean Mg level was 0.80 ± 0.23 mg/dl with lower level in the group with hypovitaminosis D than in others (0.73 ± 0.22 mg/dl vs. 0.87 ± 0.22 mg/dl, respectively) and according to t-test analysis, significant lower levels in the deficient group was observed (P = 0.0001). The linear regression analysis showed the meaningful relationship between Mg and 25(OH) D serum levels (P = 0.0001).
CONCLUSIONS
Our study revealed significant associations between serum Mg and 25(OH) D levels. This finding may be of use for further studies on the prevention and management of hypovitaminosis D in children and adolescents. Further longitudinal studies shall evaluate the underlying mechanisms and the clinical significance of the current findings.
背景
本研究旨在评估伊朗青少年全国代表性样本中血清镁和维生素D水平之间的关系。
方法
研究参与者包括330名年龄在10至18岁之间的学生，维生素D缺乏和不缺乏的个体数量相等。测定血清25羟维生素D（25(OH)D）和镁（Mg）浓度之间的相关性。
结果
参与者的平均年龄为14.74±2.587岁，维生素D缺乏者和非缺乏者之间无显著差异。维生素D缺乏组的平均25(OH)D水平为6.34±1.47 ng/ml，非缺乏组为39.27±6.42 ng/ml。平均镁水平为0.80±0.23 mg/dl，维生素D缺乏组低于其他组（分别为0.73±0.22 mg/dl和0.87±0.22 mg/dl），根据t检验分析，缺乏组的水平显著较低（P = 0.0001）。线性回归分析显示镁与血清25(OH)D水平之间存在有意义的关系（P = 0.0001）。
结论
我们的数据显示血清镁和25(OH)D水平之间存在显著关联。这一发现可能有助于进一步研究儿童和青少年维生素D缺乏的预防和管理。进一步的纵向研究应评估当前发现的潜在机制和临床意义。
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