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The mitotic origin of chromosomal instability.

作者信息

Bakhoum Samuel F, Silkworth William T, Nardi Isaac K, Nicholson Joshua M, Compton Duane A, Cimini Daniela

机构信息

Department of Biochemistry and the Norris-Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA; Department of Internal Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA 02138, USA.

Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA; Department of Chemistry and Biochemistry, UCLA, CA 90095, USA.

出版信息

Curr Biol. 2014 Feb 17;24(4):R148-9. doi: 10.1016/j.cub.2014.01.019.

DOI:10.1016/j.cub.2014.01.019
PMID:24556433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3970164/
Abstract
摘要

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本文引用的文献

1
Replication stress links structural and numerical cancer chromosomal instability.复制压力将结构和数量上的癌症染色体不稳定性联系起来。
Nature. 2013 Feb 28;494(7438):492-496. doi: 10.1038/nature11935.
2
Transient defects of mitotic spindle geometry and chromosome segregation errors.有丝分裂纺锤体几何形状的瞬时缺陷和染色体分离错误。
Cell Div. 2012 Aug 11;7(1):19. doi: 10.1186/1747-1028-7-19.
3
Deviant kinetochore microtubule dynamics underlie chromosomal instability.异常的动粒微管动力学是染色体不稳定性的基础。
Curr Biol. 2009 Dec 1;19(22):1937-42. doi: 10.1016/j.cub.2009.09.055. Epub 2009 Oct 29.
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Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.基因组稳定性通过动粒-微管动力学的时间控制得以确保。
Nat Cell Biol. 2009 Jan;11(1):27-35. doi: 10.1038/ncb1809. Epub 2008 Dec 7.
5
Overexpression of Separase induces aneuploidy and mammary tumorigenesis.Separase的过表达会诱导非整倍体和乳腺肿瘤发生。
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13033-8. doi: 10.1073/pnas.0801610105. Epub 2008 Aug 26.
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Examining the link between chromosomal instability and aneuploidy in human cells.研究人类细胞中染色体不稳定性与非整倍体之间的联系。
J Cell Biol. 2008 Feb 25;180(4):665-72. doi: 10.1083/jcb.200712029. Epub 2008 Feb 18.
7
Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells.单着丝粒动粒定向是有丝分裂的哺乳动物组织细胞中染色体数目异常的主要机制。
J Cell Biol. 2001 Apr 30;153(3):517-27. doi: 10.1083/jcb.153.3.517.
8
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.中心体扩增和不稳定性仅发生在非整倍体而非二倍体结直肠癌细胞系中，并且与染色体数目畸变相关。
Genes Chromosomes Cancer. 2000 Feb;27(2):183-90.
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Mutations of mitotic checkpoint genes in human cancers.人类癌症中纺锤体检查点基因的突变
Nature. 1998 Mar 19;392(6673):300-3. doi: 10.1038/32688.
10
Genetic instability in colorectal cancers.结直肠癌中的基因不稳定性。
Nature. 1997 Apr 10;386(6625):623-7. doi: 10.1038/386623a0.