Hall K, Lundin G, Póvoa G
Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.
Acta Endocrinol (Copenh). 1988 Jul;118(3):321-6. doi: 10.1530/acta.0.1180321.
The low molecular weight form of insulin-like growth factor binding protein (35 kD IGFBP), determined in serum by radioimmunoassay during non-fasting conditions, was high at birth and declined with increasing age during childhood and adolescence (N = 149). Inverse correlation was found between chronological age and 35 kD IGFBP values (r = -0.61, P less than 0.001) during childhood and adolescence, but no age dependency was found in adult subjects aged 20-66 years (N = 73). The mean and 95% confidence limits of immunoreactive 35 kD IGFBP were 34 micrograms/l and 15-79 micrograms/l, respectively, in healthy adults (N = 73) in whom the blood samples were drawn after a one-night fast. The mean level of the 35 kD IGFBP in patients with acromegaly (19 micrograms/l, N = 23) was decreased by 50% in comparison with healthy adults, whereas a 2-fold elevation of the mean levels was found in both anorexia nervosa patients (70 micrograms/l, N = 13) and adult patients with GH deficiency (69 micrograms/l, N = 22). In patients with anorexia nervosa, the 35 kD IGFBP levels were inversely related to the body mass index (r = -0.65, P less than 0.02).
在非空腹状态下通过放射免疫分析法测定血清中的低分子量胰岛素样生长因子结合蛋白（35kD IGFBP），出生时含量较高，在儿童期和青春期随年龄增长而下降（N = 149）。在儿童期和青春期，实足年龄与35kD IGFBP值呈负相关（r = -0.61，P < 0.001），但在20 - 66岁的成年受试者中未发现年龄依赖性（N = 73）。在健康成年人（N = 73）中，经过一夜禁食后采集血样，免疫反应性35kD IGFBP的平均值及95%置信区间分别为34μg/L和15 - 79μg/L。与健康成年人相比，肢端肥大症患者的35kD IGFBP平均水平（19μg/L，N = 23）降低了50%，而神经性厌食症患者（70μg/L，N = 13）和成年生长激素缺乏患者（69μg/L，N = 22）的平均水平均升高了2倍。在神经性厌食症患者中，35kD IGFBP水平与体重指数呈负相关（r = -0.65，P < 0.02）。
