Reeve J G, Payne J A, Bleehen N M
Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, UK.
Br J Cancer. 1990 May;61(5):727-31. doi: 10.1038/bjc.1990.163.
The production of insulin-like growth factor I (IGF-I) and IGF-I binding proteins (BPs) by human lung tumour cell lines in vitro has been examined and the levels of these substances in the serum of lung cancer patients investigated. While small cell lung cancer (SCLC) cell lines secreted both IGF-I and BPs, non-small cell lung cancer (NSCLC) cell lines secreted BPs only. No evidence of increased serum IGF-I levels was obtained in a cohort of 52 lung cancer patients having SCLC and NSCLC histologies. In contrast, serum levels of low molecular weight BPs were markedly elevated in the majority of lung cancer patients.
已对人肺肿瘤细胞系在体外产生胰岛素样生长因子I（IGF-I）和IGF-I结合蛋白（BPs）的情况进行了检测，并对肺癌患者血清中这些物质的水平进行了研究。小细胞肺癌（SCLC）细胞系可分泌IGF-I和BPs，而非小细胞肺癌（NSCLC）细胞系仅分泌BPs。在一组52例组织学类型为SCLC和NSCLC的肺癌患者中，未发现血清IGF-I水平升高的证据。相比之下，大多数肺癌患者血清中低分子量BPs水平显著升高。
