Takahashi Tsutomu, Nakamura Yumiko, Nakamura Yukako, Aleksic Branko, Takayanagi Yoichiro, Furuichi Atsushi, Kido Mikio, Nakamura Mihoko, Sasabayashi Daiki, Ikeda Masashi, Noguchi Kyo, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio, Suzuki Michio
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan; Department of Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan.
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:166-71. doi: 10.1016/j.pnpbp.2014.02.005. Epub 2014 Feb 20.
An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p = 0.004) and decreased Type I (p = 0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p = 0.005) and an increase in Type I (p = 0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.
眶额皮质（OFC）中脑沟回模式的改变在精神分裂症中被认为是神经发育异常的一个可能标志，但其遗传机制尚不清楚。这项磁共振成像研究调查了YWHAE（rs28365859）基因多态性与“H形”脑沟（I型、II型和III型）的OFC亚型之间的关系，YWHAE基因编码与神经元发育相关的14-3-3ε，是一种与精神分裂症1（DISC1）相互作用的分子。该研究选取了72例日本精神分裂症患者和86名健康对照作为样本。与对照组相比，精神分裂症患者右半球III型表达显著增加（p = 0.004），I型表达减少（p = 0.013）。与G等位基因纯合子相比，携带保护性C等位基因的受试者III型减少（p = 0.005），I型增加（p = 0.017），尤其是左半球的健康受试者。这些结果表明YWHAE基因型可能在OFC脑沟回模式的早期发育中起作用，但其单独作用不太可能解释精神分裂症中脑沟回模式的改变。
