肥胖：心血管疾病中的“重大”问题。
Obesity: the 'huge' problem in cardiovascular diseases.
作者信息
Ashraf M Javed, Baweja Paramdeep
机构信息
Department of Medicine, Cardiology Division at the Truman Medical Center and the University of Missouri-Kansas City School of Medicine, USA.
出版信息
Mo Med. 2013 Nov-Dec;110(6):499-504.
Abstract
Obesity is an epidemic in the United States. It is an independent risk factor for cardiovascular diseases and associated with reduced life expectancy. The adverse effects are related to direct impact of obesity on cardiovascular system and indirectly through its influence on risk factors. Excessive accumulation of adipose tissue in the myocardium leads to structural and functional alteration. In addition, numerous hormones secreted by adipose tissue create pro-inflammatory and prothrombotic state. This predisposes to coronary heart disease, heart failure, and sudden death. Even those with normal weight but excessive body fat are at risk. Weight reduction and exercise are the main therapeutic options.
摘要
肥胖在美国是一种流行病。它是心血管疾病的独立危险因素，与预期寿命缩短有关。其不良影响与肥胖对心血管系统的直接影响以及通过其对危险因素的影响间接相关。心肌中脂肪组织的过度积累会导致结构和功能改变。此外，脂肪组织分泌的多种激素会导致促炎和促血栓形成状态。这易引发冠心病、心力衰竭和猝死。即使是体重正常但体脂过多的人也有风险。减轻体重和运动是主要的治疗选择。
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