Katelaris P M, Cossart Y E, Rose B R, Thompson C H, Sorich E, Nightingale B, Dallas P B, Morris B J
Department of Urology, St. Vincent's Hospital, Darlinghurst, Australia.
J Urol. 1988 Aug;140(2):300-5. doi: 10.1016/s0022-5347(17)41588-6.
Human papillomavirus infection currently is accepted as a major factor in the etiology of carcinoma of the cervix, vagina and vulva. While the nature of genital human papillomavirus infection in women is well documented, detailed knowledge of the disease in the male partners is lacking. Therefore, a prospective study was done to define the disease in the genitals of heterosexual men and to formulate an appropriate plan of management. We studied 52 men during an 8-month period for evidence of genital human papillomavirus infection. The majority of the lesions occurred on the shaft of the penis and on the foreskin of uncircumcised men. Deoxyribonucleic acid dot hybridization of biopsies of macroscopic warts and suspected warty lesions with mixed human papillomavirus types 6 and/or 11 and 16 and/or 18 probes revealed that 87 and 55 per cent, respectively, were positive for 1 or more of these human papillomavirus types. Of the macroscopic warts and subclinical lesions 52 and 29 per cent, respectively, contained the more potentially oncogenic types 16 and/or 18, either alone or in combination with types 6 and/or 11. There was no evidence of human papillomavirus in any semen or urine sample but human papillomavirus deoxyribonucleic acid sequences were detected in 31 per cent of the biopsies from apparently normal penile skin and in 18 per cent of the urethral mucosal biopsies. We suggest that management of human papillomavirus infection be directed toward prevention and contact screening, together with ablation of localized lesions.
目前，人乳头瘤病毒感染被公认为是子宫颈癌、阴道癌和外阴癌病因中的一个主要因素。虽然女性生殖器人乳头瘤病毒感染的情况已有充分记录，但对男性伴侣中该疾病的详细了解却很缺乏。因此，我们进行了一项前瞻性研究，以明确异性恋男性生殖器的疾病情况，并制定适当的治疗方案。在8个月的时间里，我们对52名男性进行了研究，以寻找生殖器人乳头瘤病毒感染的证据。大多数病变发生在阴茎体和未行包皮环切术男性的包皮上。用6型和/或11型以及16型和/或18型混合人乳头瘤病毒探针，对肉眼可见的疣和疑似疣状病变的活检组织进行脱氧核糖核酸斑点杂交，结果显示，分别有87%和55%的样本对1种或多种这些人乳头瘤病毒呈阳性。在肉眼可见的疣和亚临床病变中，分别有52%和29%含有更具潜在致癌性的16型和/或18型，单独或与6型和/或11型组合存在。在任何精液或尿液样本中均未发现人乳头瘤病毒的证据，但在明显正常的阴茎皮肤活检组织中，31%检测到了人乳头瘤病毒脱氧核糖核酸序列，在尿道黏膜活检组织中，18%检测到了该序列。我们建议，人乳头瘤病毒感染的治疗应针对预防和接触者筛查，同时切除局部病变。
