Department of Microbiology, Faculty of Medicine, Brawijaya University/Dr. Saiful Anwar Hospital, Malang, Indonesia; Department of Microbiology, Faculty of Medicine, Udayana University/Sanglah Hospital, Denpasar, Bali, Indonesia; Department of Microbiology, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital, Surabaya, Indonesia; Department of Microbiology, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia; Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal; Center for Optical Diagnostics and Therapy, Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
Am J Trop Med Hyg. 2014 Apr;90(4):728-34. doi: 10.4269/ajtmh.13-0734. Epub 2014 Feb 24.
Data of Staphylococcus aureus carriage in Indonesian hospitals are scarce. Therefore, the epidemiology of S. aureus among surgery patients in three academic hospitals in Indonesia was studied. In total, 366 of 1,502 (24.4%) patients carried S. aureus. The methicillin-resistant S. aureus (MRSA) carriage rate was 4.3%, whereas 1.5% of the patients carried Panton-Valentine leukocidin (PVL)-positive methicillin-sensitive S. aureus (MSSA). Semarang and Malang city (odds ratio [OR] 9.4 and OR 9.0), being male (OR 2.4), hospitalization for more than 5 days (OR 11.708), and antibiotic therapy during hospitalization (OR 2.6) were independent determinants for MRSA carriage, whereas prior hospitalization (OR 2.5) was the only one risk factor for PVL-positive MSSA carriage. Typing of MRSA strains by Raman spectroscopy showed three large clusters assigned type 21, 24, and 38, all corresponding to ST239-MRSA-SCCmec type III. In conclusion, MRSA and PVL-positive MSSA are present among patients in surgical wards in Indonesian academic hospitals.
印度尼西亚医院金黄色葡萄球菌携带的数据很少。因此，研究了印度尼西亚三所学术医院外科患者金黄色葡萄球菌的流行病学。共有 1502 名患者中的 366 名携带金黄色葡萄球菌。耐甲氧西林金黄色葡萄球菌（MRSA）携带率为 4.3%，而 1.5%的患者携带产 Panton-Valentine 白细胞素（PVL）的甲氧西林敏感金黄色葡萄球菌（MSSA）。三宝垄和玛琅市（比值比[OR]9.4 和 OR9.0）、男性（OR2.4）、住院时间超过 5 天（OR11.708）和住院期间抗生素治疗（OR2.6）是 MRSA 携带的独立决定因素，而先前的住院治疗（OR2.5）是 PVL 阳性 MSSA 携带的唯一危险因素。通过拉曼光谱对 MRSA 菌株进行分型显示，三个大簇被分配为 21 型、24 型和 38 型，均与 ST239-MRSA-SCCmec 型 III 相对应。总之，印度尼西亚学术医院外科病房的患者中存在 MRSA 和产 PVL 的 MSSA。
