Zeng Huawei, Lazarova Darina L, Bordonaro Michael
Huawei Zeng, United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58203, United States.
World J Gastrointest Oncol. 2014 Feb 15;6(2):41-51. doi: 10.4251/wjgo.v6.i2.41.
Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host's metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer.
许多流行病学和实验研究表明，膳食纤维在预防结肠癌方面发挥着重要作用。这些发现可能与纤维减少致癌物在肠腔内接触时间的能力以及促进健康的肠道微生物群有关，肠道微生物群以多种方式改变宿主的新陈代谢。阐明膳食纤维依赖的肠道微生物群变化增强胆汁酸去结合、产生短链脂肪酸以及调节炎症生物活性物质的机制，有助于更好地理解膳食纤维的有益作用。本文综述了关于膳食纤维预防结肠癌机制的现有知识。
