非HIV免疫抑制患者的隐球菌感染——肾脏病环境下的三例病例报告
Cryptococcal infection in non-HIV immunosuppressed patients - Three case reports in a nephrology setting.
作者信息
Ventura Aguiar Pedro, Lopes Virgínia, Martins La Salete, Santos Josefina, Almeida Manuela, Pedroso Sofia, Dias Leonídio, Castro Henriques António, Ramos Helena, Cabrita António
机构信息
Nephrology Department - Oporto Hospital Centre, Largo Professor Abel Salazar, 4099-001 Porto, Portugal.
Microbiology Department - Oporto Hospital Centre, Largo Professor Abel Salazar, 4099-001 Porto, Portugal.
出版信息
Med Mycol Case Rep. 2013 Dec 4;3:14-6. doi: 10.1016/j.mmcr.2013.11.003. eCollection 2014 Jan.
Abstract
Cryptococcal infection has been increasing among immunosuppressed population. We report three cases of Cryptococcus neoformans infection in immunosuppressed patients - two renal transplanted and one with lupus nephritis. Early infection (<3months) was diagnosed in two - an allograft Cryptococcus infection and a central nervous system involvement. The third, a 10-year transplant vintage patient, presented with cryptococcal meningitis. Amphotericin B provided good clinical outcomes. We outline the importance of suspicion for cryptococcal infection in immunosuppressed patients.
摘要
隐球菌感染在免疫抑制人群中呈上升趋势。我们报告了3例免疫抑制患者的新型隐球菌感染病例——2例肾移植患者和1例狼疮性肾炎患者。2例患者诊断为早期感染（<3个月）——1例为移植肾隐球菌感染，另1例累及中枢神经系统。第3例是一位肾移植术后10年的患者，表现为隐球菌性脑膜炎。两性霉素B治疗取得了良好的临床效果。我们强调了对免疫抑制患者隐球菌感染保持警惕的重要性。
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本文引用的文献
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Curr Microbiol. 2014 Feb;68(2):199-203. doi: 10.1007/s00284-013-0452-0.
2
Cryptococcus gattii infections in multiple states outside the US Pacific Northwest.美国太平洋西北地区以外多个州的新型隐球菌感染。
Emerg Infect Dis. 2013 Oct;19(10):1620-6. doi: 10.3201/eid1910.130441.
3
American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis.美国风湿病学会狼疮性肾炎筛查、治疗及管理指南。
Arthritis Care Res (Hoboken). 2012 Jun;64(6):797-808. doi: 10.1002/acr.21664.
4
Early-onset of disseminated cryptococcal infection in two renal transplant recipients.
Clin Nephrol. 2011 Jun;75(6):542-6. doi: 10.5414/cn106772.
5
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6
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7
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9
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