Ventura Aguiar Pedro, Lopes Virgínia, Martins La Salete, Santos Josefina, Almeida Manuela, Pedroso Sofia, Dias Leonídio, Castro Henriques António, Ramos Helena, Cabrita António
Nephrology Department - Oporto Hospital Centre, Largo Professor Abel Salazar, 4099-001 Porto, Portugal.
Microbiology Department - Oporto Hospital Centre, Largo Professor Abel Salazar, 4099-001 Porto, Portugal.
Med Mycol Case Rep. 2013 Dec 4;3:14-6. doi: 10.1016/j.mmcr.2013.11.003. eCollection 2014 Jan.
Cryptococcal infection has been increasing among immunosuppressed population. We report three cases of Cryptococcus neoformans infection in immunosuppressed patients - two renal transplanted and one with lupus nephritis. Early infection (<3months) was diagnosed in two - an allograft Cryptococcus infection and a central nervous system involvement. The third, a 10-year transplant vintage patient, presented with cryptococcal meningitis. Amphotericin B provided good clinical outcomes. We outline the importance of suspicion for cryptococcal infection in immunosuppressed patients.
隐球菌感染在免疫抑制人群中呈上升趋势。我们报告了3例免疫抑制患者的新型隐球菌感染病例——2例肾移植患者和1例狼疮性肾炎患者。2例患者诊断为早期感染（<3个月）——1例为移植肾隐球菌感染，另1例累及中枢神经系统。第3例是一位肾移植术后10年的患者，表现为隐球菌性脑膜炎。两性霉素B治疗取得了良好的临床效果。我们强调了对免疫抑制患者隐球菌感染保持警惕的重要性。
