a Natural Products Laboratory, Institute of Biology, Leiden University , Leiden , The Netherlands.
Biotechnol Genet Eng Rev. 2013;29:187-205. doi: 10.1080/02648725.2013.801238. Epub 2013 Aug 2.
Zebrafish offer a unique vertebrate model for research areas such as drug development, disease modeling and other biological exploration. There is significant conservation of genetics and other cellular networks among zebrafish and other vertebrate models, including humans. Here we discuss the recent work and efforts made in different fields of biology to explore the potential of zebrafish. Along with this, we also reviewed the concept of systems biology. A biological system is made up of a large number of components that interact in a huge variety of combinations. To understand completely the behavior of a system, it is important to know its components and interactions, and this can be achieved through a systems biology approach. At the end of the paper we present a concept of integrating zebrafish into the systems biology approach.
斑马鱼为药物开发、疾病建模和其他生物探索等领域提供了独特的脊椎动物模型。斑马鱼和其他脊椎动物模型（包括人类）在遗传学和其他细胞网络方面有显著的保守性。在这里，我们讨论了不同生物学领域的最新工作和努力，以探索斑马鱼的潜力。与此同时，我们还回顾了系统生物学的概念。一个生物系统由大量以各种组合相互作用的组件组成。为了完全了解系统的行为，了解其组件和相互作用非常重要，这可以通过系统生物学的方法来实现。在论文的最后，我们提出了将斑马鱼整合到系统生物学方法中的概念。
