University of Burgundy, Dijon, F-21000, France.
Food Funct. 2014 Apr;5(4):663-70. doi: 10.1039/c3fo60417a.
Various epidemiological studies have shown that a regular and moderate consumption of red wine is correlated with a decreased relative risk of developing coronary heart disease and cancer. These health benefits are commonly attributed to high contents of polyphenols, particularly resveratrol, representing important sources of antioxidants. However, resveratrol does not seem to be the only bioactive compound present in the wine which contains numerous other polyphenols. The present study investigates the efficiency of red wine extracts (RWEs), containing different polyphenols, on colon cancer cell proliferation in vitro and on colonic aberrant crypt foci (ACF) in vivo. Proliferation, cell cycle analysis and incidence of ACF were monitored to examine the effects of RWEs. RWEs derived from a long vinification process exhibit superior anti-proliferative activity in colon cancer cells and prevent the appearance of ACF in mice. Interestingly, quercetin and resveratrol, representing two major bio-active polyphenols, exhibit synergistic anti-proliferative effects. These data suggest that the efficacy of RWEs on colon carcinogenesis may depend on the polyphenolic content, synergistic interaction of bio-active polyphenols and modulation of cellular uptake of polyphenols.
各种流行病学研究表明，适量饮用红酒与降低冠心病和癌症的相对风险有关。这些健康益处通常归因于多酚含量高，特别是白藜芦醇，它是抗氧化剂的重要来源。然而，白藜芦醇似乎不是葡萄酒中唯一存在的生物活性化合物，葡萄酒还含有许多其他多酚。本研究调查了含有不同多酚的红酒提取物（RWE）对体外结肠癌细胞增殖和体内结肠异常隐窝病灶（ACF）的影响。监测增殖、细胞周期分析和 ACF 的发生率，以检查 RWE 的作用。从长时间发酵过程中提取的 RWE 对结肠癌细胞具有优异的抗增殖活性，并可防止小鼠出现 ACF。有趣的是，槲皮素和白藜芦醇，这两种主要的生物活性多酚，表现出协同的抗增殖作用。这些数据表明，RWE 对结肠癌发生的疗效可能取决于多酚含量、生物活性多酚的协同作用以及多酚细胞摄取的调节。
