Departamento de Ingeniería Electrónica, Instituto I3BH, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
Europace. 2014 Mar;16(3):405-15. doi: 10.1093/europace/eut405.
Ischaemic heart disease is considered as the single most frequent cause of death, provoking more than 7 000 000 deaths every year worldwide. A high percentage of patients experience sudden cardiac death, caused in most cases by tachyarrhythmic mechanisms associated to myocardial ischaemia and infarction. These diseases are difficult to study using solely experimental means due to their complex dynamics and unstable nature. In the past decades, integrative computational simulation techniques have become a powerful tool to complement experimental and clinical research when trying to elucidate the intimate mechanisms of ischaemic electrophysiological processes and to aid the clinician in the improvement and optimization of therapeutic procedures. The purpose of this paper is to briefly review some of the multiscale computational models of myocardial ischaemia and infarction developed in the past 20 years, ranging from the cellular level to whole-heart simulations.
缺血性心脏病被认为是全球范围内导致死亡的最常见原因，每年导致超过 700 万人死亡。很大一部分患者会经历心源性猝死，这在大多数情况下是由与心肌缺血和梗死相关的快速性心律失常机制引起的。由于这些疾病具有复杂的动力学和不稳定的特性，因此仅使用实验手段很难对其进行研究。在过去的几十年中，综合计算模拟技术已成为一种强大的工具，可用于补充实验和临床研究，以阐明缺血性电生理过程的内在机制，并帮助临床医生改进和优化治疗程序。本文的目的是简要回顾过去 20 年来在心肌缺血和梗死方面开发的一些多尺度计算模型，范围从细胞水平到整个心脏模拟。
