葡萄牙东北部花朵中鉴定出的酚类化合物对念珠菌属的抗真菌活性。
Antifungal activity of phenolic compounds identified in flowers from North Eastern Portugal against Candida species.
作者信息
Alves Carlos Tiago, Ferreira Isabel C F R, Barros Lillian, Silva Sónia, Azeredo Joana, Henriques Mariana
机构信息
IBB-Institute for Biotechnology & Bioengineering, Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.
出版信息
Future Microbiol. 2014;9(2):139-46. doi: 10.2217/fmb.13.147.
AIM
To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells.
MATERIALS & METHODS: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification of colony-forming units.
RESULTS
MIC values demonstrated that gallic acid presented the highest effect against all Candida species. Catechin showed a similar effect against Candida albicans American Type Culture Collection (ATCC) 90028 cells. In addition, gallic acid and quercetin had demonstrated only a minimal effect against Candida species biofilms.
CONCLUSION
Gallic acid affected the growth of the different planktonic Candida species in all concentrations used; still, catechin showed a similar effect against C. albicans ATCC 90028 and Candida glabrata ATCC 2001 cells. In addition, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms.
目的
评估没食子酸、儿茶素、木犀草素和槲皮素（从葡萄牙东北部花朵中鉴定出的酚类化合物）对白色念珠菌浮游细胞和生物膜细胞的抗真菌作用。
材料与方法
测定白色念珠菌浮游细胞的最低抑菌浓度（MIC），并通过菌落形成单位的定量评估酚类化合物对白色念珠菌生物膜的影响。
结果
MIC值表明没食子酸对所有念珠菌属具有最高的抑菌效果。儿茶素对白色念珠菌美国典型培养物保藏中心（ATCC）90028细胞显示出类似的效果。此外，没食子酸和槲皮素对念珠菌属生物膜仅显示出最小的作用。
结论
没食子酸在所使用的所有浓度下均影响不同浮游念珠菌属的生长；不过，儿茶素对白色念珠菌ATCC 90028和光滑念珠菌ATCC 2001细胞显示出类似的效果。此外，只有没食子酸和槲皮素对所有念珠菌属生物膜显示出轻微作用。
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