来自人类疫苗接种者的T细胞对狂犬病及狂犬病相关病毒的识别。
Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients.
作者信息
Celis E, Ou D, Dietzschold B, Koprowski H
机构信息
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
出版信息
J Virol. 1988 Sep;62(9):3128-34. doi: 10.1128/JVI.62.9.3128-3134.1988.
Abstract
Human peripheral blood mononuclear cells and T-cell lines and clones from individuals immunized with rabies PM vaccine were tested for the ability to recognize antigenic determinants in rabies and rabies-related viruses in an antigen-induced proliferation assay. Some, but not all, of the T cells from these individuals cross-reacted with various laboratory strains of rabies virus with rabies-related viruses such as Duvenhage and Mokola. In addition, these T cells were shown to react with epitopes of either the ribonucleoprotein or the viral glycoprotein. Rabies-specific cytotoxic T-cell responses by a CD4+ T-cell line were evident against antigenic determinants of the ribonucleoprotein and glycoprotein.
摘要
在用狂犬病PM疫苗免疫的个体中获取人外周血单核细胞以及T细胞系和克隆，通过抗原诱导增殖试验检测它们识别狂犬病病毒和狂犬病相关病毒中抗原决定簇的能力。这些个体的部分（而非全部）T细胞能与多种狂犬病病毒实验室毒株以及杜文海格病毒和莫科拉病毒等狂犬病相关病毒发生交叉反应。此外，这些T细胞显示出与核糖核蛋白或病毒糖蛋白的表位发生反应。一个CD4 + T细胞系产生的针对核糖核蛋白和糖蛋白抗原决定簇的狂犬病特异性细胞毒性T细胞反应很明显。
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