超敏反应研究。II. 豚鼠对变性蛋白的迟发型超敏反应。
Studies on hypersensitivity. II. Delayed hypersensitivity to denatured proteins in guinea pigs.
作者信息
GELL P G, BENACERRAF B
出版信息
Immunology. 1959 Jan;2(1):64-70.
The capacity of denatured proteins to provoke anaphylactic sensitivity and delayed sensitivity in guinea pigs has been investigated. It has been found that heat-denatured proteins are as effective as native proteins in provoking delayed hypersensitivity to either material, in spite of the fact that such denaturation greatly modifies their antigenicity from the point of view of antibody production. Pure delayed hypersensitivity, moreover, occurs regularly in response to extremely minute amounts of a good antigen, whether native or denatured. It is further shown that immunological cross-reactivity can be demonstrated regularly by means of the delayed hypersensitivity reaction in guinea pigs, at a time when no cross-reacting antibodies of conventional type can be found. The significance of these observations in regard to the relationship between delayed hypersensitivity and antibody production is discussed.
已对变性蛋白质引发豚鼠过敏敏感性和迟发型敏感性的能力进行了研究。结果发现，热变性蛋白质在引发对这两种物质的迟发型超敏反应方面与天然蛋白质一样有效，尽管从抗体产生的角度来看，这种变性极大地改变了它们的抗原性。此外，无论抗原是天然的还是变性的，纯迟发型超敏反应通常会对极微量的优质抗原产生反应。进一步表明，在无法检测到常规类型的交叉反应抗体时，通过豚鼠的迟发型超敏反应可经常证明免疫交叉反应性。讨论了这些观察结果对于迟发型超敏反应与抗体产生之间关系的意义。
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