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嵌合植物抗体可被动保护小鼠免受雾化蓖麻毒素攻击。

Chimeric plantibody passively protects mice against aerosolized ricin challenge.

作者信息

Sully Erin K, Whaley Kevin J, Bohorova Natasha, Bohorov Ognian, Goodman Charles, Kim Do H, Pauly Michael H, Velasco Jesus, Hiatt Ernie, Morton Josh, Swope Kelsi, Roy Chad J, Zeitlin Larry, Mantis Nicholas J

机构信息

Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.

出版信息

Clin Vaccine Immunol. 2014 May;21(5):777-82. doi: 10.1128/CVI.00003-14. Epub 2014 Feb 26.

DOI:10.1128/CVI.00003-14
PMID:24574537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4018890/
Abstract

Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation.

摘要

美国及国外近期发生的事件加剧了人们对蓖麻毒素作为生物恐怖主义制剂使用的担忧。在本研究中，我们利用一个强大的植物平台制备了四种嵌合毒素中和单克隆抗体，然后评估了它们被动保护小鼠免受致死剂量蓖麻毒素攻击的能力。最有效的抗体c-PB10，在小鼠经注射和吸入接触蓖麻毒素后，作为一种治疗药物进行了进一步评估。

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Clin Vaccine Immunol. 2014 May;21(5):777-82. doi: 10.1128/CVI.00003-14. Epub 2014 Feb 26.
2
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本文引用的文献

1
Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA).蓖麻毒素酶亚基（RTA）上非线性中和 B 细胞表位的定位。
Immunol Lett. 2014 Mar-Apr;158(1-2):7-13. doi: 10.1016/j.imlet.2013.11.009. Epub 2013 Nov 21.
2
Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail.用 MB-003 单克隆抗体鸡尾酒疗法治疗恒河猴的埃博拉病毒感染。
Sci Transl Med. 2013 Aug 21;5(199):199ra113. doi: 10.1126/scitranslmed.3006608.
3
Current biodefense vaccine programs and challenges.当前的生物防御疫苗计划和挑战。
Hum Vaccin Immunother. 2013 Jul;9(7):1591-7. doi: 10.4161/hv.24063. Epub 2013 Feb 21.
4
Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.植物源单克隆抗体延迟埃博拉病毒感染治疗可为恒河猴提供保护。
Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18030-5. doi: 10.1073/pnas.1213709109. Epub 2012 Oct 15.
5
Sub-domains of ricin's B subunit as targets of toxin neutralizing and non-neutralizing monoclonal antibodies.蓖麻毒素 B 亚基的亚结构域作为毒素中和和非中和单克隆抗体的靶标。
PLoS One. 2012;7(9):e44317. doi: 10.1371/journal.pone.0044317. Epub 2012 Sep 11.
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Transient and stable expression of antibodies in Nicotiana species.抗体在烟草属植物中的瞬时表达和稳定表达。
Methods Mol Biol. 2012;907:389-408. doi: 10.1007/978-1-61779-974-7_23.
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Emerging antibody-based products.新兴的抗体类产品。
Curr Top Microbiol Immunol. 2014;375:107-26. doi: 10.1007/82_2012_240.
8
Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit.解析蓖麻毒素酶亚基中溶剂暴露的免疫显性α-螺旋内两个重叠的中和 B 细胞表位。
Toxicon. 2012 Oct;60(5):874-7. doi: 10.1016/j.toxicon.2012.06.014. Epub 2012 Jun 29.
9
The need for continued development of ricin countermeasures.蓖麻毒素应对措施持续发展的必要性。
Adv Prev Med. 2012;2012:149737. doi: 10.1155/2012/149737. Epub 2012 Mar 26.
10
Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit.植物表达部分人源化抗蓖麻毒素 A 亚单位免疫优势表位的中和单克隆 IgG。
Vaccine. 2012 Feb 8;30(7):1239-43. doi: 10.1016/j.vaccine.2011.12.058. Epub 2011 Dec 22.