Adebayo Abiodun Humphrey, John-Africa Lucy Binda, Agbafor Amarachi Grace, Omotosho Omolola Elizabeth, Mosaku Timothy Olusoji
Biochemistry & Molecular Biology Unit, Department of Biological Sciences, Covenant University, PMB 1023, Canaan Land, Ota, Nigeria.
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research & Development (NIPRD), Abuja, Nigeria.
Pak J Pharm Sci. 2014 Mar;27(2):265-70.
Anchomanes difformis is a tropical plant that has been used in folklore to treat diverse complications. The leaf extract of A. difformis was investigated for possible anti-nociceptive and anti-inflammatory effects in albino wistar rats. In these independent studies, two sets of twenty five rats were divided into five groups of five rats per group. Formalin induced pain in rats was used to investigate the anti-nociceptive effect of the extract. The extract was administered orally in the treated groups at doses 200, 400, 800 and 1600 mg/kg with aspirin serving as the positive drug control while the normal control group was not given any extract but water. Studies were also carried out on the egg albumin induced anti-inflammatory activity in rats by inducing oedema on the left hind paw. The result showed a significant inhibition (p<0.05) on the later phase (800mg/kg) of formalin pain induction in rats; similarly, a significant (p<0.05) anti-inflammatory activity was observed at 60, 90 and 120 minutes. The study thus validates the ethnomedicinal usage of A. difformis in the treatment of pain and inflammation.
异叶非洲白星海芋是一种热带植物，在民间传说中被用于治疗各种并发症。对白化Wistar大鼠研究了异叶非洲白星海芋叶提取物可能的抗伤害感受和抗炎作用。在这些独立研究中，将两组共25只大鼠分为五组，每组五只。用福尔马林诱导大鼠疼痛来研究提取物的抗伤害感受作用。在治疗组中，提取物以200、400、800和1600mg/kg的剂量口服给药，阿司匹林作为阳性药物对照，而正常对照组未给予任何提取物，只给予水。还通过在大鼠左后爪诱导水肿来研究蛋清诱导的大鼠抗炎活性。结果显示，对大鼠福尔马林疼痛诱导的后期阶段（800mg/kg）有显著抑制作用（p<0.05）；同样，在60、90和120分钟时观察到显著的（p<0.05）抗炎活性。因此，该研究证实了异叶非洲白星海芋在治疗疼痛和炎症方面的民族药用价值。
