Zerihun Muluken Fekadie, Malik Tabarak, Ferede Yohannes Mulu, Bekele Tesfahun, Yeshaw Yigizie
Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Nursing Department, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
BMC Res Notes. 2019 Aug 15;12(1):512. doi: 10.1186/s13104-019-4555-y.
Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant.
The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p = 0.02 for mean body weight and p = 0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value = 0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.
醋酸甲羟孕酮避孕针（Depo-Provera）是一种含醋酸甲羟孕酮的注射用避孕方法。它有一些不良反应，如月经模式改变、骨矿物质密度降低和体重增加风险。因此，本研究旨在调查醋酸甲羟孕酮避孕针对埃塞俄比亚女性体重和血压的影响。2017年1月至2017年4月进行了基于机构的横断面研究设计。使用SPSS 21版软件进行数据分析。采用配对t检验、独立t检验和方差分析来评估均值差异的存在以及变量变化与醋酸甲羟孕酮避孕针使用时间之间的关系。P值≤0.05被认为具有统计学意义。
醋酸甲羟孕酮避孕针使用者的平均体重和体重指数（BMI）显著增加（平均体重p = 0.02，体重指数p = 0.019）。与对照组或其各自的治疗前值相比，醋酸甲羟孕酮避孕针使用者的平均动脉血压（MAP）没有显著差异（醋酸甲羟孕酮避孕针使用者的p值 = 0.85，非使用者的p值 = 0.67）。本研究结果显示，与非使用者相比，醋酸甲羟孕酮避孕针使用者的体重增加和BMI升高，这确实需要卫生专业人员和其他利益相关者予以关注。
